Prof. John Rostas
| Work Phone | (02) 4921 5615 |
|---|---|
| Fax | (02) 4921 5669 |
| John.Rostas@newcastle.edu.au | |
| Office | LS3-40 and BB2-04, Life Sciences And Bowman |
Highlighted Publications
| Year | Citation | Link |
|---|---|---|
| 2006 | Migues Paola Virginia, Lehmann Ingo Tobias, Fluechter Lisa, Cammarota Martin Pablo, Gurd J W, Sim Alistair Thomas, Dickson Phillip Wesley, Rostas John Andrew, 'Phosphorylation of CaMKII at Thr253 occurs in vivo and enhances binding to isolated postsynaptic densities', Journal of Neurochemistry, 98 289-299 (2006) [C1] |
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| 2004 | Lengyel Imre, Voss K, Cammarota Martin Pablo, Bradshaw K, Brent Vicki Annette, Murphy K P S J, Giese K P, Rostas John Andrew, Bliss T V P, 'Autonomous activity of CaMKII is only transiently increased following the induction of long-term potentiation in the rat hippocampus', European Journal of Neuroscience, 20 3063-3072 (2004) [C1] |
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| 2001 | Lengyel Imre, Cammarota Martin Pablo, Brent Vicki Annette, Rostas John Andrew, 'Autonomous activity and autophosphorylation of CAMPK-II in rat hippocampal slices: effects of tissue preparation', Journal of Neurochemistry, 76 149-154 (2001) [C1] |
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| 2004 | Xue J, Tsang Cw, Gai W-P, Malladi Cs, Trimble Ws, Rostas John Andrew, Robinson Pj, 'Septin 3 (G-septin) is a developmentally regulated phosphoprotein enriched in presynaptic nerve terminals', Journal of Neurochemistry, 91(3) 579-590 (2004) [C1] |
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| 2010 | Atkinson Rebbekah Josephine, Rostas John Andrew, Hunter Michael, 'Changes in mid-to-late latency auditory evoked responses in the chicken during neural maturation', Developmental Psychobiology, 52 24-34 (2010) [C1] |
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Publications
For items published while at an institution other that the University of Newcastle, details are shown in italics.
Click on a category title below to expand the list of citations for that specific category.
Chapters In A Book (2 outputs)
Chapter in A1 Book (B1) (2 outputs)
| Year | Citation | Link |
|---|---|---|
| 2012 | Skelding Kathryn Anne, Rostas John Andrew, 'The role of molecular regulation and targeting in regulating calcium/calmodulin stimulated protein kinases', Calcium Signaling, Springer New York LLC, New York, NY, 703-730 (2012) [B1] | |
| 2010 | Atkinson Rebbekah Josephine, Rosso Osvaldo Anibal, Figliola Alejandra, Serrano Eduardo, Moscato Pablo Alberto, Hunter Michael, Rostas John Andrew, 'Use of the domestic chicken to investigate mechanisms of brain maturation', Translational Neuroscience and Its Advancement of Animal Research Ethics, Nova Science Publishers, Hauppauge, 29-53 (2010) [B1] |
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Journal Articles (41 outputs)
Refereed Article in a Scholarly Journal (C1) (37 outputs)
| Year | Citation | Link |
|---|---|---|
| 2012 | Skelding Kathryn Anne, Spratt Neil James, Fluechter Lisa, Dickson Phillip Wesley, Rostas John Andrew, 'alpha CaMKII is differentially regulated in brain regions that exhibit differing sensitivities to ischemia and excitotoxicity', Journal of Cerebral Blood Flow and Metabolism, 32 2181-2192 (2012) [C1] | |
| 2011 | Skelding Kathryn Anne, Rostas John Andrew, Verrills Nicole Margaret, 'Controlling the cell cycle: The role of calcium/calmodulin-stimulated protein kinases I and II', Cell Cycle, 10 631-639 (2011) [C1] | |
| 2010 | Atkinson Rebbekah Josephine, Rostas John Andrew, Hunter Michael, 'Changes in mid-to-late latency auditory evoked responses in the chicken during neural maturation', Developmental Psychobiology, 52 24-34 (2010) [C1] |
|
| 2010 | Skelding Kathryn Anne, Suzuki Tatsuo, Gordon Sarah Louise, Xue Jing, Verrills Nicole Margaret, Dickson Phillip Wesley, Rostas John Andrew, 'Regulation of CaMKII by phospho-Thr253 or phospho-Thr286 sensitive targeting alters cellular function', Cellular Signalling, 22 759-769 (2010) [C1] |
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| 2009 | Rosso Osvaldo Anibal, Mendes Alexandre De Sousa, Berretta Regina Esther, Rostas John Andrew, Hunter Michael, Moscato Pablo Alberto, 'Distinguishing childhood absence epilepsy patients from controls by the analysis of their background brain electrical activity (II): A combinatorial optimization approach for electrode selection', Journal of Neuroscience Methods, 181 257-267 (2009) [C1] |
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| 2009 | Rosso Osvaldo Anibal, Mendes Alexandre De Sousa, Rostas John Andrew, Hunter Michael, Moscato Pablo Alberto, 'Distinguishing childhood absence epilepsy patients from controls by the analysis of their background brain electrical activity', Journal of Neuroscience Methods, 177 461-468 (2009) [C1] |
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| 2009 | Skelding Kathryn Anne, Rostas John Andrew, 'Regulation of CaMKII in vivo: The importance of targeting and the intracellular microenvironment', Neurochemical Research, 34 1792-1804 (2009) [C1] |
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| 2008 | Atkinson Rebbekah Josephine, Migues Paola Virginia, Cammarota Martin, Kavanagh Jacinta Mary, Hunter Michael, Rostas John Andrew, 'Biochemical, behavioural and electrophysiological investigations of brain maturation in chickens', Brain Research Bulletin, 76 217-223 (2008) [C1] |
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| 2008 | Atkinson Rebbekah Josephine, Migues Paola Virginia, Hunter Michael, Rostas John Andrew, 'Molecular changes in the intermediate medial mesopallium after a one trial avoidance learning in immature and mature chickens', Journal of Neurochemistry, 104 891-902 (2008) [C1] |
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| 2008 | Gurd James W, Rawof Salma, Zhen Huo Jeanne, Dykstra Crystal, Bissoon Nankie, Teves Lucy, Wallace M Christopher, Rostas John Andrew, 'Ischemia and status epilepitcus result in enhanced phosphorylation of calcium and calmodulin-stimulated protein kinase II on threonine 253', Brain Research, 1218 158-165 (2008) [C1] |
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| 2007 | Migues Paola Virginia, Cammarota Martin Pablo, Kavanagh J, Atkinson Rebbekah Josephine, Powis David Alan, Rostas John Andrew, 'Maturational changes in the subunit composition of AMPA receptors and the functional consequences of their activation in chicken forebrain', Developmental Neuroscience, 29 232-240 (2007) [C1] | |
| 2006 | Baldwin Monique Louise, Cammarota Martin Pablo, Sim Alistair Thomas, Rostas John Andrew, 'Src family tyrosine kinases differentially modulate exocytosis from rat brain nerve terminals', Neurochemistry International, 49 80-86 (2006) [C1] | |
| 2006 | Migues Paola Virginia, Lehmann Ingo Tobias, Fluechter Lisa, Cammarota Martin Pablo, Gurd J W, Sim Alistair Thomas, Dickson Phillip Wesley, Rostas John Andrew, 'Phosphorylation of CaMKII at Thr253 occurs in vivo and enhances binding to isolated postsynaptic densities', Journal of Neurochemistry, 98 289-299 (2006) [C1] |
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| 2006 | Sim Alistair Thomas, Herd Lynn Michelle, Proctor D T, Baldwin Monique Louise, Meunier F A, Rostas John Andrew, 'High throughput analysis of endogenous glutamate release using a fluorescence plate reader', Journal of Neuroscience Methods, 153 43-47 (2006) [C1] | |
| 2005 | Hunter Michael, Smith Robert Lloyd, Hyslop Wendy Anne, Rosso O A, Gerlach Richard Helmut, Rostas John Andrew, Williams D B, Henskens Frans Alexander, 'The Australian EEG database', Clinical EEG & Neuroscience, 36 76-81 (2005) [C1] |
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| 2005 | Rosso O A, Hyslop Wendy Anne, Gerlach Richard Helmut, Smith Robert Lloyd, Rostas John Andrew, Hunter Michael, 'Quantitative EEG analysis of the maturational changes associated with childhood absence epilepsy', Physica A -Statistical Mechanics and Its Applications, 356 184-189 (2005) [C1] | |
| 2004 | Lengyel Imre, Voss K, Cammarota Martin Pablo, Bradshaw K, Brent Vicki Annette, Murphy K P S J, Giese K P, Rostas John Andrew, Bliss T V P, 'Autonomous activity of CaMKII is only transiently increased following the induction of long-term potentiation in the rat hippocampus', European Journal of Neuroscience, 20 3063-3072 (2004) [C1] |
|
| 2004 | Xue J, Milburn Pj, Hanna Bt, Graham Me, Rostas John Andrew, Robinson Pj, 'Phosphorylation of septin 3 on Ser-91 by cGMP-dependent protein kinase-I in nerve terminals', Biochem J, 381 753-760 (2004) [C1] | |
| 2004 | Xue J, Tsang Cw, Gai W-P, Malladi Cs, Trimble Ws, Rostas John Andrew, Robinson Pj, 'Septin 3 (G-septin) is a developmentally regulated phosphoprotein enriched in presynaptic nerve terminals', Journal of Neurochemistry, 91(3) 579-590 (2004) [C1] |
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| 2003 | Atkinson Rebbekah Josephine, Bevilaqua Lia, Rostas John Andrew, Hunter Michael, 'Discriminative taste aversion learning: A learning task for older chickens', Neurobiology of Learning and Memory, 79 25-31 (2003) [C1] |
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| 2003 | Baldwin Monique Louise, Rostas John Andrew, Sim Alistair Thomas, 'Two modes of excytosis from synaptosomes are differentially regulated by protein phosphatase types 2A and 2B', Journal of Neurochemistry, 85 1190-1199 (2003) [C1] |
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| 2003 | Cammarota Martin Pablo, Bevilaqua Lia, Rostas John Andrew, Dunkley Peter Robert, 'Histamine activates tyrosine hydroxylase in bovine adrenal chromaffin cells through a pathway that involves ERK1/2 but not p38 or JNK', Journal of Neurochemistry, 84 453-458 (2003) [C1] | |
| 2003 | Sim Alistair Thomas, Baldwin Monique Louise, Rostas John Andrew, Holst Jeff, Ludowyke Russell I, 'The role of serine/threonine protein phosphatases in exocytosis', Biochemical Journal, 373 641-659 (2003) [C1] | |
| 2001 | Cammarota Martin Pablo, Bevilaqua Lia, Dunkley Peter Robert, Rostas John Andrew, 'Angiotensin II Promotes the Phosphorylation of Cyclic AMP-Responsive Element Binding Protein (CREB) at Ser133 Through an ERK1/2-Dependent Mechanism', Journal of Neurochemistry, 79 1122-1128 (2001) [C1] | |
| 2001 | Lengyel Imre, Cammarota Martin Pablo, Brent Vicki Annette, Rostas John Andrew, 'Autonomous activity and autophosphorylation of CAMPK-II in rat hippocampal slices: effects of tissue preparation', Journal of Neurochemistry, 76 149-154 (2001) [C1] |
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| 2001 | Lengyel Imre, Nairn Ac, McCluskey A, Toth G, Penke B, Rostas John Andrew, 'Auto-inhibition of Ca2+/calmodulin-dependent protein kinase II by its ATP-binding domain', Journal of Neurochemistry, 76 1066-1072 (2001) [C1] | |
| 2000 | Hunter M, Battilana M, Bragg T, Rostas John Andrew, 'EEG as a Measure of Developmental Changes in the Chicken Brain', Developmental Psychobiology, 36 23-28 (2000) [C1] | |
| 2000 | Lengyel Imre, Fieuw-Makaroff Sabine, Hall Alison Louise, Sim Alistair Thomas, Rostas John Andrew, Dunkley Peter Robert, 'Modulation of the Phosphorylation and Activity of Calcium/Calmodulin-Dependent Protein Kinase II by Zinc', Journal of Neurochemistry, 75 No. 2 594-605 (2000) [C1] |
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| 2000 | Margrie Troy William, Rostas John Andrew, Sah P, 'Inhibition of transmitter release and long-term depression in the avian hippocampus', Neuroscience Letters, 284 17-20 (2000) [C1] | |
| 2000 | Xue Jing, Wang X, Malladi C S, Kinoshita M, Milburn P J, Lengyel Imre, Rostas John Andrew, Robinson P J, 'Phosphorylatin of a new brain-specific septin, G-Septin, by cyclic-GMP dependent protein kinase', Biological Chemistry, 275 10047-10056 (2000) [C1] | |
| 1999 | Lengyel Imre, Olson Leslie George, Nichol Ka, Brain Kl, Wang X, Robinson Phillip James, Bennett Mr, Rostas John Andrew, 'Phosphorylation of proteins in chick ciliary ganglion under conditions that induce long-lasting changes in synaptic transmission: phosphoprotein targets for nitric oxide action', Neuroscience, 90 No. 2 607-619 (1999) [C1] | |
| 1998 | Capon R J, Rooney F, Murray L M, Collins Elizabeth, Sim Alistair Thomas, Rostas John Andrew, Butler M S, Carroll A R, 'Dragmacidins: New protein phosphatase inhibitors from a Southern Australian deep-water marine sponge Spongosorites sp', Journal of Natural Products, 61 660-662 (1998) [C1] | |
| 1998 | Lengyel Imre, Nichol K A, Bennett M R, Heath J W, Little G J, Rostas John Andrew, 'Alpha and beta subunits of CaM-kinase II are localized in different neurons in chick ciliary ganglion', NeuroReport, 9(12) 2753-2755 (1998) [C1] | |
| 1998 | Margrie Troy William, Rostas John Andrew, Sah P, 'Long-term potentiation of synaptic transmission in the avian hippocampus', The Journal of Neuroscience, 18(4) 1207-1216 (1998) [C1] | |
| 1998 | Margrie Troy William, Rostas John Andrew, Sah P, 'Presynaptic long-term depression at a central glutamatergic synapse: a role for CaMKII', Nature Neuroscience, 1(5) 378-383 (1998) [C1] | |
| 1998 | Sim Alistair Thomas, Collins Elizabeth, Mudge L M, Rostas John Andrew, 'Developmental regulation of protein phosphatase types 1 and 2A in post-hatch chicken brain', Neurochemical Research, 23(4) 487-491 (1998) [C1] | |
| 1998 | Wang X, Rostas John Andrew, 'Protein phosphorylation in fast and slow chicken skeletal muscles: Effect of denervation', Muscle and Nerve, 21 504-513 (1998) [C1] | |
| Show 34 more | ||
Non Refereed Article in a Professional Journal (C3) (1 outputs)
| Year | Citation | Link |
|---|---|---|
| 2008 | Gibbs Marie E, Gibbs Colin, Csillag Andras, Matsushima Toshiya, Rogers Lesley, Rostas John Andrew, 'Brain mechanisms, cognition and behaviour in birds', Brain Research Bulletin, 76 167-169 (2008) [C3] |
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Letter or Note (C4) (2 outputs)
| Year | Citation | Link |
|---|---|---|
| 2001 | Cammarota Martin Pablo, Bevilaqua Lia, Dunkley Peter Robert, Rostas John Andrew, 'Angiotensin II Promotes a Rapid and Reversible Increase in SRC-Tyrosine Kinase Activity in Bovine Adrenal Chromaffin Cells: Effect on MAPK Pathways', Proceedings of the Australian Neuroscience Society, 12 197 (2001) [C4] | |
| 2001 | Cammarota Martin Pablo, Bevilaqua Lia, Dunkley Peter Robert, Rostas John Andrew, 'Angiotensin II Promotes a Src and ERK 1/2 Dependent Increase in SER133-CREB Phosphorylation', Journal of Neurochemistry, 78 Supl. 1 143 (2001) [C4] |
Other Refereed Contribution to a Scholarly Journal (C5) (1 outputs)
| Year | Citation | Link |
|---|---|---|
| 2003 | Hunter Michael, Rostas John Andrew, Hyslop Wendy Anne, 'The John Hunter Hospital EEG database project', Australian Journal of Psychology, 55 104 (2003) [C5] |
Conference Publication (25 outputs)
Full Written Paper - Refereed (E1) (2 outputs)
| Year | Citation | Link |
|---|---|---|
| 2007 | Fernandez J G, Larrondo H A, Figliola A, Serrano E, Rostas John Andrew, Hunter Michael, Rosso O A, 'Brain maturation changes characterized by algorithmic complexity (lempel and ziv complexity)', Nonequilibrium Statistical Mechanics and Nonlinear Physics: XV Conference on Nonequilibrium Statistical Mechanics and Nonlinear Physics. AIP Conference Proceedings, Mar del Plata, Argentina (2007) [E1] | |
| 2007 | Figliola A, Serrano E, Rostas John Andrew, Hunter Michael, Rosso O A, 'Study of EEG brain maturation signals with multifractal detrended fluctuation analysis', Nonequilibrium Statistical Mechanics and Nonlinear Physics: XV Conference on Nonequilibrium Statistical Mechanics and Nonlinear Physics. AIP Conference Proceedings, Mar del Plato, Argentina (2007) [E1] |
Extract of Paper (E3) (23 outputs)
| Year | Citation | Link |
|---|---|---|
| 2012 | Abdul Majeed A'Qilah Banu Binte, Skelding Kathryn Anne, Dickson Phillip Wesley, Rostas John Andrew, 'Does phosphorylation of CaMKII at multiple sites regulate CaMKII targeting co-operatively or independently?', Abstracts. Australian Neuroscience Society 32nd Annual Meeting, Gold Coast, Queensland (2012) [E3] | |
| 2012 | Rostas John Andrew, Skelding Kathryn Anne, Fluechter Lisa, Dickson Phillip Wesley, Spratt Neil James, 'CaMKII is differentially regulated in striatum and cortex', Journal of Molecular Neuroscience: Abstracts The 21st Annual Meeting of the Israel Society for Neuroscience & The First Binational Australian-Israeli Meeting in Neuroscience, Eilat, Israel (2012) [E3] | |
| 2012 | Skelding Kathryn Anne, Abdul Majeed A'Qilah Banu Binte, Dickson Phillip Wesley, Spratt Neil James, Rostas John Andrew, 'CAMKII is regulated differently in brains regions with differing sensitivities to ischaemia/excitotoxicity', Abstracts. Australian Neuroscience Society 32nd Annual Meeting, Gold Coast, Queensland (2012) [E3] | |
| 2012 | Skelding Kathryn Anne, Dickson Phillip Wesley, Verrills Nicole Margaret, Rostas John Andrew, 'Dephosphorylation of CAMKII at T253 controls progression through metaphase', Abstracts. Australian Neuroscience Society 32nd Annual Meeting, Gold Coast, Queensland (2012) [E3] | |
| 2011 | Skelding Kathryn Anne, Chung S, Pepperall Debbie-Gai, Tomkins Amelia Jane, Spratt Neil James, Rostas John Andrew, 'The role of CaMKII in neuronal sensitivity to ischaemia', Oral abstracts. Australian Neuroscience Society Annual Meeting, Auckland, NZ (2011) [E3] | |
| 2010 | Rostas John Andrew, Skelding Kathryn Anne, 'The role of targeting in the regulation of CaMKII in vivo', OzBio 2010: The Molecules of Life - from Discovery to Biotechnology Symposium Abstracts, Melbourne, Vic (2010) [E3] | |
| 2010 | Skelding Kathryn Anne, Tomkins Amelia Jane, Fluechter Lisa, Pepperall Debbie-Gai, Spratt Neil James, Rostas John Andrew, 'Ischaemia-induced CaMKII phosphorylation in hypertensive and normotensive rats', Proceding of the Australian Neuroscience Society, Sydney, NSW (2010) [E3] | |
| 2010 | Skelding Kathryn Anne, Verrills Nicole Margaret, Dickson Phillip Wesley, Rostas John Andrew, 'Regulation of proliferation of neuroblastoma cells by CaMKII', Proceding of the Australian Neuroscience Society, Sydney, NSW (2010) [E3] | |
| 2010 | Skelding Kathryn Anne, Xue Jing, Suzuki T, Verrills Nicole Margaret, Dickson Phillip Wesley, Rostas John Andrew, 'Mechanisms of phosphorylation-sensitive CaMKII targeting', Proceding of the Australian Neuroscience Society, Sydney, NSW (2010) [E3] | |
| 2009 | Rostas John Andrew, 'Regulation of CaMKII activity', ANS 2009 Abstracts: Symposia, Canberra, ACT (2009) [E3] | |
| 2009 | Rostas John Andrew, Skelding Kathryn Anne, Liao Xiaomei, Verrills Nicole Margaret, Dickson Phillip Wesley, 'Regulation of CaMKII by targeting', Proceedings of the 2nd Australia-China Biomedical Research Conference, - (2009) [E3] | |
| 2009 | Rostas John Andrew, Skelding Kathryn Anne, Verrills Nicole Margaret, Suzuki P W, Dickson T, 'CaMKII binding partners vary with cell type and phosphorylation state', Journal of Neurochemistry, Busan, Korea (2009) [E3] | |
| 2009 | Skelding Kathryn Anne, Liao X, Verrills Nicole Margaret, Fluechter Lisa, Dickson Phillip Wesley, Rostas John Andrew, 'CaMKII phosphorylation at T253 alters neuronal growth rates and morphology', Journal of Neurochemistry, Busan, Korea (2009) [E3] | |
| 2009 | Skelding Kathryn Anne, Liao X, Verrills Nicole Margaret, Fluechter Lisa, Sim Alistair Thomas, Dickson Phillip Wesley, Rostas John Andrew, 'Functional consequences of CaMKII phosphorylation at THR253 in neurons', ANS 2009 Abstracts: Posters, Canberra, ACT (2009) [E3] | |
| 2009 | Tomkins Amelia Jane, Rostas John Andrew, Pepperall Debbie-Gai, Calford Michael Brian, Spratt Neil James, 'Infarction occurs more rapidly in hypertensive rats', ANS 2009 Abstracts: Posters, Canberra, ACT (2009) [E3] | |
| 2008 | Skelding Kathryn Anne, Verrills Nicole Margaret, Fluechter Lisa, Sim Alistair Thomas, Dickson Phillip Wesley, Rostas John Andrew, 'Development of a novel method for the identification of CaMKII binding proteins', Journal of Neurochemistry, Shanghai, China (2008) [E3] | |
| 2008 | Skelding Kathryn Anne, Verrills Nicole Margaret, Fluechter Lisa, Sim Alistair Thomas, Dickson Phillip Wesley, Rostas John Andrew, 'Identification of CaMKII binding proteins in brain sensitive to CaMKII phosphorylation state', Proceedings of the Australian Neuroscience Society, Hobart, TAS (2008) [E3] | |
| 2007 | Hunter Michael, Atkinson Rebbekah Josephine, Rostas John Andrew, 'Perturbed maturation in chicken forebrain via the induction of mild hypothyroidism: developmental changes measured by auditory event related potentials (Poster)', 7th IBRO 2007 World Congress of Neuroscience Program, Melbourne (2007) [E3] | |
| 2006 | Atkinson Rebbekah Josephine, Thomas (Duff) L, Migues Paola Virginia, Fluechter Lisa, Rostas John Andrew, Hunter Michael, 'Perturbed maturation in the chicken forebrain by the induction of late onset mild hypo-thyroidsim', Proceedings of the Australian Neuroscience Society, Sydney (2006) [E3] | |
| 2006 | Rostas John Andrew, Migues Paola Virginia, Fluechter Lisa, Dickson Phillip Wesley, Sim Alistair Thomas, Rawoff S, Bissoon N, Wallace M C, Gurd James Wood, 'Phosphorylation of CAMKII at T253 induced by transient global ischaemia', Proceedings of the Australian Neuroscience Society, Sydney (2006) [E3] | |
| 2005 | Atkinson Rebbekah Josephine, Migues Paola Virginia, Fluechter Lisa, Hunter Michael, Rostas John Andrew, 'Biochemical characterisation of maturational changes in components of glutamatergic synapses in the chick IMHV', Australian Neuroscience Society: Proceedings of the 25th Annual, Perth, Australia (2005) [E3] | |
| 2004 | Migues Paola Virginia, Sim Alistair Thomas, Rostas John Andrew, 'Changes in KCI-induced phosphorylation of AMPA and NMDA receptors during chicken brain maturation', Journal of Neurochemistry, Hong Kong (2004) [E3] | |
| 2004 | Rostas John Andrew, Baldwin Monique Louise, Cammarota Martin Pablo, Sim Alistair Thomas, 'The regulation of synaptosomal exocytosis by Src tyrosine kinases', Journal of Neurochemistry, Hong Kong (2004) [E3] | |
| Show 20 more | ||