| 2025 |
Teng L, Feng YC, Guo ST, Wang PL, Qi TF, Yue YM, Wang SX, Zhang SN, Tang CX, La T, Zhang YY, Zhao XH, Gao JN, Wei LY, Zhang D, Wang JY, Shi Y, Liu XY, Li JM, Cao H, Liu T, Thorne RF, Jin L, Shao F-M, Zhang XD, 'Author Correction: The pan-cancer lncRNA PLANE regulates an alternative splicing program to promote cancer pathogenesis.', Nat Commun, 16 (2025)
Correction to: Nature Communicationshttps://doi.org/10.1038/s41467-021-24099-4, published online 18 June 2021 In the version of the article initially published there we... [more]
Correction to: Nature Communicationshttps://doi.org/10.1038/s41467-021-24099-4, published online 18 June 2021 In the version of the article initially published there were errors in Fig. 2c and f. In Fig. 2c, the NCI-H226 si-PLANE.2 image was incorrect and from another experimental replicate of HCT116 si-PLANE.2. In Fig. 2f, the three images in A549. shPLANE.2 (-Dox, +Dox and Dox withdrawal) are incorrect, and from images of A549 si-ctrl, si-PLANE.1 from Fig. 2c and another experimental replicate of A549 si-PLANE.2, respectively. In Fig. 2f, the three images of stained cell colonies shown in H1299.shPLANE.1 (-Dox, +Dox and Dox withdrawal) are incorrect and from images of H1299 si-ctrl, si-PLANE.1 and parental from Fig. 2c respectively. The original and corrected Fig. 2c and f are shown below. The figure has been corrected in the PDF and HTML versions of the article. The raw data for Fig.¿2 are included as¿Supplementary information alongside the online version of the article. Fig. 1 Original and corrected Fig. 2c and f Original Figure: (Figure presented.) Corrected Figure: (Figure presented.)
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| 2025 |
Xu L, Zhao XH, Zhang YY, Zhang MY, Zhang LY, Ye KH, Teng L, Han MM, Yue YM, Yang J, Ogle R, Netherton J, Tang D, Lan S, Baker M, Ye Y, Liu T, Wang YF, Zhang XD, Fan T, Jin L, 'SNORD80-guided 2’-O-methylation stabilizes the lncRNA GAS5 to regulate cellular stress responses', Proceedings of the National Academy of Sciences of the United States of America, 122 (2025) [C1]
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| 2025 |
Zhao XH, Han MM, Yan QQ, Yue YM, Ye K, Zhang YY, Teng L, Xu L, Shi XJ, La T, Feng YC, Xu R, Narayana VK, De Souza DP, Quek LE, Holst J, Liu T, Baker MA, Thorne RF, Zhang XD, Jin L, 'DNA replication stress underpins the vulnerability to oxidative phosphorylation inhibition in colorectal cancer', Cell Death and Disease, 16 (2025) [C1]
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| 2024 |
Xu L, Meng L, Xiang W, Wang X, Yang J, Shu C, Zhao XH, Rong Z, Ye Y, 'Prohibitin 2 confers NADPH oxidase 1-mediated cytosolic oxidative signaling to promote gastric cancer progression by ERK activation', FREE RADICAL BIOLOGY AND MEDICINE, 224, 130-143 (2024) [C1]
Oxidative signaling plays a dual role in tumor initiation and progression to malignancy; however, the regulatory mechanisms of oxidative stress in gastric cancer remain... [more]
Oxidative signaling plays a dual role in tumor initiation and progression to malignancy; however, the regulatory mechanisms of oxidative stress in gastric cancer remain to be explored. In this study, we discovered that Prohibitin 2 (PHB2) specifically regulates cytosolic reactive oxygen species production in gastric cancer and facilitates its malignant progression. Previously, we found that PHB2 is upregulated in gastric cancer, correlating with increased tumorigenicity of gastric cancer cells and poor patient prognosis. Here, we discovered that PHB2 expression correlates with the activation of the ERK/MAPK cascade, positively regulating the top gene NADPH oxidase 1 (NOX1) within this pathway. Further mechanistic investigation reveals that PHB2 enhances NOX1 transcription by interacting with the transcription factor C/EBP-beta and promoting its translocation into the nucleus, resulting in elevated intracellular oxidative signaling driven by NOX1, which subsequently activates ERK. Therefore, we propose that targeting PHB2-C/EBP-beta-NOX1-mediated cytosolic oxidative stress could offer a promising therapeutic avenue for combating gastric cancer malignant progression.
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| 2024 |
Zheng SM, Feng YC, Zhu Q, Li RQ, Yan QQ, Teng L, Yue YM, Han MM, Ye K, Zhang SN, Qi TF, Tang CX, Zhao XH, Zhang YY, Xu L, Xu R, Xing J, Baker M, Liu T, Thorne RF, Jin L, Preiss T, Zhang XD, Cang S, Gao JN, 'MILIP Binding to tRNAs Promotes Protein Synthesis to Drive Triple-Negative Breast Cancer', CANCER RESEARCH, 84, 1460-1474 (2024) [C1]
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Open Research Newcastle |
| 2024 |
Xu L, Xiang W, Yang J, Gao J, Wang X, Meng L, Ye K, Zhao XH, Zhang XD, Jin L, Ye Y, 'PHB2 promotes SHIP2 ubiquitination via the E3 ligase NEDD4 to regulate AKT signaling in gastric cancer', JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, 43 (2024) [C1]
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Open Research Newcastle |
| 2024 |
Xu Q, La T, Ye K, Wang L, Wang S, Hu Y, Teng L, Yan L, Li J, Zhang Z, Shao Z, Zhang YY, Zhao XH, Feng YC, Jin L, Baker M, Thorne RF, Zhang XD, Shao F-M, Cao H, 'KMT2A and chronic inflammation as potential drivers of sporadic parathyroid adenoma', CLINICAL AND TRANSLATIONAL MEDICINE, 14 (2024) [C1]
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Open Research Newcastle |
| 2023 |
Li RQ, Zhao XH, Zhu Q, Liu T, Hondermarck H, Thorne RF, Zhang XD, Gao JN, 'Exploring neurotransmitters and their receptors for breast cancer prevention and treatment', THERANOSTICS, 13, 1109-1129 (2023) [C1]
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Open Research Newcastle |
| 2023 |
La T, Chen S, Zhao XH, Zhou S, Xu R, Teng L, Zhang YY, Ye K, Xu L, Guo T, Jamaluddin MF, Feng YC, Tang HJ, Wang Y, Xu Q, Gu Y, Cao H, Liu T, Thorne RF, Shao F-M, Zhang XD, Jin L, 'LncRNA LIMp27 Regulates the DNA Damage Response through p27 in p53-Defective Cancer Cells', ADVANCED SCIENCE, 10 (2023) [C1]
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Open Research Newcastle |
| 2022 |
Wang PL, Teng L, Feng YC, Yue YM, Han MM, Yan Q, Ye K, Tang CX, Zhang SN, Qi TF, Zhao XH, La T, Zhang YY, Li JM, Bin H, Xu D, Cang S, Li W, Jin L, Thorne RF, Zhang Y, Liu T, Zhang XD, 'The N-Myc-responsive lncRNA MILIP promotes DNA double-strand break repair through non-homologous end joining', PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 119 (2022) [C1]
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Open Research Newcastle |
| 2021 |
Teng L, Feng YC, Guo ST, Wang PL, Qi TF, Yue YM, Wang SX, Zhang SN, Tang CX, La T, Zhang YY, Zhao XH, Gao JN, Wei LY, Zhang D, Wang JY, Shi Y, Liu XY, Li JM, Cao H, Liu T, Thorne RF, Jin L, Shao F-M, Zhang XD, 'The pan-cancer lncRNA PLANE regulates an alternative splicing program to promote cancer pathogenesis', NATURE COMMUNICATIONS, 12 (2021) [C1]
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Open Research Newcastle |
| 2021 |
La T, Chen S, Guo T, Zhao XH, Teng L, Li D, Carnell M, Zhang YY, Feng YC, Cole N, Brown AC, Zhang D, Dong Q, Wang JY, Cao H, Liu T, Thorne RF, Shao F-M, Zhang XD, Jin L, 'Visualization of endogenous p27 and Ki67 reveals the importance of a c-Myc-driven metabolic switch in promoting survival of quiescent cancer cells', THERANOSTICS, 11, 9605-9622 (2021) [C1]
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Open Research Newcastle |
| 2021 |
Feng YC, Zhao XH, Teng L, Thorne RF, Jin L, Zhang XD, 'The pan-cancer lncRNA MILIP links c-Myc to p53 repression', MOLECULAR & CELLULAR ONCOLOGY, 8 (2021)
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| 2018 |
Zhang S, Zhu Q, Chen X, Zhao Y, Zhao X, Yang Y, Gao Z, Fang T, Wang Y, Zhang J, 'Forensic applicability of multi-allelic InDels with mononucleotide homopolymer structures', ELECTROPHORESIS, 39, 2136-2143 (2018) [C1]
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| 2018 |
Zhao Y, Chen X, Yang Y, Zhao X, Zhang S, Gao Z, Fang T, Wang Y, Zhang J, 'Potential forensic biogeographic application of diatom colony consistency analysis employing pyrosequencing profiles of the 18S rDNA V7 region', INTERNATIONAL JOURNAL OF LEGAL MEDICINE, 132, 1611-1620 (2018) [C1]
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| 2018 |
Zhao Y, Mao Z, Pang H, Zhao X, Zhang S, Gao Z, Yang Y, Fang T, Ma Q, Ma X, Wang Y, Zhang J, 'Association of programmed cell death 1 (PDCD1 ) gene polymorphisms with colorectal cancer among Han Chinese population', Chinese Journal of Medical Genetics, 35, 219-223 (2018)
Objective To assess the association of programmed cell death 1 (PDCD1) gene polymorphisms with the susceptibility and/or progression of colorectal cancer. Methods A hos... [more]
Objective To assess the association of programmed cell death 1 (PDCD1) gene polymorphisms with the susceptibility and/or progression of colorectal cancer. Methods A hospital-based case-control study was carried out, which recruited 426 colorectal cancer patients and 500 healthy individuals. Five single nucleotide polymorphisms, namely rs36084323, rsll568821, rs2227981, rs2227982 and rsl0204525, were selected for the study and genotyped with a polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP) assay. Results The G allele of rs36084323 under a dominant model was associated with increased risk of advanced TNM staging of colorectal cancer progression (OR = 1.59, 95% CI = 1.02-2.48). Haplotypes G-G-C-T-A and A-G-C-C-G of the rs36084323, rsll568821, rs2227981, rs2227982, and rsl0204525 were negatively associated with the occurrence of colorectal cancer. Conclusion The G allele of rs36084323 is associated with increased risk of advanced TNM staging of colorectal cancer. Conversely, the incidence of colorectal cancer is negatively associated with the haplotypes G-G-C-T-A and A-G-C-C-G of rs36084323, rsll568821, rs2227981, rs2227982, and rs10204525.
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| 2018 |
Gao Z, Chen X, Zhao Y, Zhao X, Zhang S, Yang Y, Wang Y, Zhang J, 'Forensic genetic informativeness of an SNP panel consisting of 19 multi-allelic SNPs', FORENSIC SCIENCE INTERNATIONAL-GENETICS, 34, 49-56 (2018) [C1]
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| 2018 |
Zhao X, Chen X, Zhao Y, Zhang S, Gao Z, Yang Y, Wang Y, Zhang J, 'Construction and forensic genetic characterization of 11 autosomal haplotypes consisting of 22 tri-allelic indels', FORENSIC SCIENCE INTERNATIONAL-GENETICS, 34, 71-80 (2018) [C1]
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| 2017 |
Zhao Y, Zhao X, Zhang S, Gao Z, Yang Y, Fang T, Wang Y, Zhang J, 'A short unix shell script for vcftools commands iteration to obtain the genotypes of variations for forensic purpose', Forensic Science International Genetics Supplement Series, 6, e49-e51 (2017) [C1]
The release of 1000 Genomes Project has provided a great variety of genome-wide variations spanning major populations worldwide, which offered a convenient path to the ... [more]
The release of 1000 Genomes Project has provided a great variety of genome-wide variations spanning major populations worldwide, which offered a convenient path to the study of human genetic structure. VCFtools, a suite of functions dedicated to loci details summarizing, calculating, filtering, and genotype outputting can act as a powerful utility for genetic markers hunting and evaluating in the context of forensic purpose. While it is a labor-intensive and error-prone job involving repeating of multiple VCFtools commands step by step. Hence, we introduced a short UNIX-based bash shell script which contains an iteration structure to call VCFtools commands repeatedly for summarizing genotypes in different variation loci of different populations automatically. By setting up variations list and groups list, VCFtools commands with different arguments can be executed consecutively. Consequently, this process can be realized automatically with high efficiency and precision in the study of forensic genetics.
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