Professor Michael Nilsson
Honorary Professor
School of Medicine and Public Health
- Email:michael.nilsson@newcastle.edu.au
- Phone:+61 2 4042 0570
Career Summary
Biography
Professor Michael Nilsson MD, PhD, is the Director of the Centre for Rehab Innovations (CRI) and Global Innovation Chair of Rehabilitation Medicine at the University of Newcastle. He is a Fellow of the Australasian Faculty of Rehabilitation Medicine, The Royal Australasian College of Physicians.
Michael is the immediate-past Director of the Hunter Medical Research Institute (HMRI) and Burges Professor of Medical Science, Newcastle, Australia 2012-2018. Prior to his appointment at HMRI, he was the Director of Rehabilitation Medicine, and the Neuro Division; and Director of Research and Development at Sahlgrenska University Hospital, Gothenburg, Sweden 2000-2012.
Michael is an internationally recognised researcher, leader and innovator in Health and Medicine, and a senior specialist in Rehabilitation Medicine with a well-established translational research platform in discovery and clinical neuroscience.
He recently founded CRI (www.centrerehabinnovations.com.au) together with long-term collaborator Professor Rohan Walker and other senior colleagues at the University of Newcastle and HMRI. With strong and established links to national and international expertise, CRI explores new avenues in precision rehabilitation targeting individual needs. Innovative, interdisciplinary tools and programs are developed, evaluated and implemented in community and home settings, and within rehabilitation centres. CRI engages with different stakeholders in Healthcare and related industry to evaluate and deliver sustainable, effective solutions as a part of their rehabilitation, recovery and preventative strategies.
Over the course of his career, Michael Nilsson has developed and implemented new models of care, and evaluated care trajectories in Rehab, for instance after stroke, traumatic brain injury and Parkinson. Correlations between physical activity, multimodal stimulation/enriched environment and cognition are explored in schoolchildren, young adults and stroke patients. The correlations between cardiovascular fitness and IQ, mood, dementia, stroke and epilepsy are further investigated in interlinked projects, utilising a unique cohort of over a million conscripts in the Swedish military data registers. He has initiated projects aimed at further understanding of the outcome and impact of translational research. His lab research is focused on key cellular mechanisms underpinning resilience, brain plasticity, degeneration and neural repair and how these mechanisms are influenced by psychological stress. He also investigates the effects of the environment on stroke recovery and stress tolerance in both animal models and clinical/human settings.
He has received more than $36 million in total research funding from Australian, Swedish, European and American funding sources, including the NHMRC, Swedish Research Council, ALF, VGR, Brain Foundation and EU. Currently, he is the co-Director of the NHMRC Centre for Research Excellence in Stroke Rehabilitation and Brain Recovery.
Michael is an entrepreneur and rehabilitation thought leader, and is regularly invited speaker at international and national conferences, as well as to expert panels and consensus discussions in his field of expertise. He has developed several business projects and strong links with industrial partners in Australia and elsewhere. He holds multiple senior business advisory roles and board directorships. Michael has received awards from user organisations in rehabilitation and neurology, and quality awards for rehabilitation service delivery and accreditation processes. He is a member of the NHMRC Health Translation Advisory Committee, and a member of the RACP, AFRM Research Working Committee.
He is a Visiting Professor at the LKC School of Medicine, Nanyang Technological University (NTU), Singapore; La Trobe University, Melbourne, Australia; University of Gothenburg, Sweden; and Honorary Professor at the Florey Institute, Melbourne.
Teaching Expertise
Teaching and tutoring in undergraduate, postgraduate, postdoctoral and specialist training since 1996. He has taught and provided supervision to medical students in Rehabilitation Medicine, Neurology and Geriatric Medicine at the Faculty of Medicine, University of Gothenburg and Sahlgrenska University Hospital, Gothenburg, Sweden from 1996-2010. Topics included histology, neurobiology, glia biology, stroke, TBI, Parkinson and epilepsy, brain plasticity and regeneration, leadership. He has supervised PhD and Masters Students since 1994, either as main supervisor or co-supervisor.
Qualifications
- PhD, University of Gothenburg - Sweden
- Doctor of Medicine, University of Gothenburg - Sweden
Keywords
- Brain Repair
- Neurology
- Neuroscience
- Rehabilitation
- Stroke recovery
- Stroke rehabilitation
Languages
- Swedish (Fluent)
Fields of Research
Code | Description | Percentage |
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420109 | Rehabilitation | 50 |
320903 | Central nervous system | 30 |
420302 | Digital health | 20 |
Professional Experience
Academic appointment
Dates | Title | Organisation / Department |
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13/8/2018 - | Director, Centre for Rehab Innovations (CRI) | The University of Newcastle Australia |
13/8/2018 - | Global Innovation Chair of Rehabilitation Medicine | The University of Newcastle Australia |
1/6/2016 - | Committee Member | Royal Australasian College of Physicians Australasian Faculty of Rehabilitation Medicine, Research Working Committee |
1/8/2015 - | Committee Member | NHMRC (National Health & Medical Research Council) Health Translation Advisory Committee |
1/2/2012 - 10/8/2018 | Burges Professor of Medical Science | Faculty of Health, University of Newcastle Australia |
1/11/2006 - | Professor of Rehabilitation Medicine | University of Gothenburg Sweden |
1/1/2004 - 1/8/2006 | Director | University of Gothenburg and Sahlgrenska University Hospital Arvid Carlsson Institute Sweden |
1/10/1997 - 1/4/1998 | Visiting Academic | Flinders University Centre for Neuroscience Australia |
Professional appointment
Dates | Title | Organisation / Department |
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5/12/2016 - | Australian Medical Practitioner Registration | Australian Health Practitioner Regulation Agency Specialist Registration in Rehabilitation Medicine Australia |
18/11/2016 - | Fellow | Royal Australasian College of Physicians Australasian Faculty of Rehabilitation Medicine |
1/4/2012 - 1/8/2018 | Executive Director | Hunter Medical Research Institute (HMRI) Australia |
1/4/2011 - 1/1/2012 | Research Strategist | Sahlgrenska University Hospital Central Administration Sweden |
1/4/2010 - 1/4/2011 | Director of Research, Development and Education (RD&E) | Sahlgrenska University Hospital Sweden |
1/12/2000 - 1/4/2009 | Chair of the Senior Specialist Organisation in Rehabilitation Medicine | Region of West Sweden Sweden |
1/10/2000 - 1/4/2009 | Director and Senior Consultant | Sahlgrenska University Hospital Rehabilitation Medicine Sweden |
1/6/2000 - | Specialist in Neurology and Rehabilitation Medicine | Sahlgrenska University Hospital Sweden |
Invitations
Organiser
Year | Title / Rationale |
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2017 |
Impact and health technology assessment in health care - what is relevant for rehabilitation medicine? Organiser: Rehabilitation Medicine Society of Australia and New Zealand (RMSANZ), 2nd Annual Scientific Meeting breakfast session. Canberra, Australia |
2017 |
Brain Neuroplasticity: Understanding the Science; its influence on Clinical Practice - International perspectives Organiser: Rehabilitation Medicine Society of Australia and New Zealand (RMSANZ), 2nd Annual Scientific Meeting plenary session. Canberra, Australia |
2017 |
Improving post-stroke brain plasticity and regeneration - from basic research to the clinic Joint Organiser / Chair: The 4th Peter Eriksson Conference and the 3rd Lund-Gothenburg Stroke Research Forum. Nya Varvet, Sweden |
2017 |
The Winter Brain Conference on Brain Research Joint Organiser / Invited Speaker. Big Sky, Montana, USA |
2016 |
Centre for Research Excellence in Stroke Rehabilitation and Brain Recovery Industry Roundtable Meeting Joint Organiser: Melbourne, Australia |
2016 |
International Symposium on Respiratory Research Joint Organiser: Singapore |
Panel Participant
Year | Title / Rationale |
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2018 |
Sydney Hills Business Chamber, CEO Lunch for Medical Healthcare Invited Panelist: Sydney, Australia |
2018 |
The future of health and medical research in Tasmania? Invited Panelist: Royal Hobart Hospital Research Foundation Excellence Dinner. Hobart, Australia |
2017 |
Swedish Australian Chamber of Commerce (SACC) Entrepreneurship & Innovation Business Seminar Invited Panelist: Sydney, Australia |
2016 |
Stroke Recovery Roundtable - Stroke Recovery Translation Committee (Preclinical to clinical trials) Invited Panelist: Philadelphia, USA |
Participant
Year | Title / Rationale |
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2016 |
Harnessing care complexity for health and medical education Invited Chair: Medical Professional Development Program for Doctors. Port Stephens, Australia |
Speaker
Year | Title / Rationale |
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2019 |
Enriched environment in health and disease. A special emphasis on resilience and wellbeing for mind and body Norwest Learn SmartLife Lecture Series. Sydney, Australia |
2019 |
Stress and reactive glial cells in recovery and neurodegeneration after stroke and TBI CaRehab, Rehabilitation: Inclusivity and Innovation for individuals, institutions and communities. Singapore |
2019 |
Post-traumatic cognitive impairment: Strategies to support function recovery 7th World Intracranial Hemorrhage (WICH) Conference. Granada, Spain |
2019 |
Enriched environment as a therapeutic paradigm 2nd Hemorrhagic Stroke Academia Industry (HEADS) Roundtable. Granada, Spain |
2019 |
Building the resilient brain - how important is the environment? Chalmers University of Technology, Architecture and Health Research Symposium. Gothenburg, Sweden |
2018 |
Enriched environments and brain plasticity: implications for palliative care Australian and New Zealand Society of Palliative Medicine (ANZSPM) Conference. Sydney, Australia |
2018 |
Experiences drawn from Healthcare Startups The Bridgetech Program Residential Training. Sydney, Australia |
2018 |
Precision rehabilitation - How can technology support long term interventions? International e-mental health Conference. Newcastle, Australia |
2018 |
Music and the Brain: The role of neuroplasticity Music Interventions for Dementia in Elderly Care, University of Melbourne. Melbourne, Australia |
2018 |
Advances in Stroke Rehabilitation Stroke Recovery Association, Creating Connections Conference. Sydney, Australia |
2018 |
Plasticity of the brain in spasticity rehabilitation 5th Nordic Toxins Congress 2018. Helsingborg, Sweden |
2017 |
Is stroke a neurodegenerative condition? Illawarra Health and Medical Research Institute (IHMRI) Seminar Series. Wollongong, Australia |
2017 |
From spectator to perpetrator: How microglia impact on rehabilitation | Overview of neuroplasticity and mechanisms for the positive effects of music on the CNS Rehabilitation Medicine Society of Australia and New Zealand (RMSANZ), 2nd Annual Meeting. Canberra, Australia |
2017 |
Emerging avenues in stroke rehabilitation - focus on recovery and secondary neurodegeneration Queensland Brain Institute (QBI) Seminar Series. Brisbane, Australia |
2017 |
Stimulating environments and brain plasticity - links to resilience, prevention and recovery SPHERE 2017 Conference. Sydney, Australia |
2017 |
Brain plasticity, recovery and neurodegeneration after traumatic brain injury - a translational approach LKC Medicine, Nanyang Technological University, Traumatic Brain Injury Workshop. Singapore |
2017 |
Stroke and secondary neurodegeneration 4th Peter Eriksson Conference and the 3rd Lund-Gothenburg Stroke Research Forum. Nya Varvet, Sweden. |
2017 |
Stroke - biomarkers predictive of functional outcome and new targets in brain plasticity and regeneration The 50th Meeting of the Winter Conference on Brain Research (WCBR). Big Sky, Montana, USA. |
2016 |
Regional Innovation and Disruption: Health's contribution to regional innovation and economic growth 10th Annual Newcastle and Hunter Region Economic Development Forum, Committee for Economic Development of Australia (CEDA). Newcastle, Australia |
2016 |
The Medical Research Future Fund; doubling the federal funding of medical research in Australia Forska! Sverge (Research Sweden) Symposium, Health Challenge - Sweden's role as a research nation. Stockholm, Sweden. |
2016 |
Stress and Secondary Neurodegeneration in Stroke - Relevance for Neurorehabilitation 9th World Congress for Neurorehabilitation (WCNR 2016). Philadelphia, USA |
2015 |
Hunter Medical Research Institute Model for Effective Research Translation Swedish Australian Health Care Forum, High Quality, Safe and Efficient Health Care. Canberra, Australia |
2015 |
Enriched environment in stroke recovery International Brain Awareness Week, Brain Health Research Centre, Queenstown, New Zealand |
2015 |
Stroke rehabilitation practice and research - can you justify what your instincts tell you! AFRM Rehabilitation Medicine ASM Stroke Workshop. Wellington, New Zealand |
Publications
For publications that are currently unpublished or in-press, details are shown in italics.
Chapter (12 outputs)
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2021 |
Karayanidis F, Kelly M, Nilsson PM, 'Music and the Brain across the Lifespan', The Science and Psychology of Music From Mozart at the Office to Beyoncé at the Gym, Greenwood. ABC-CLIO, Santa Barbara, California 100-104 (2021) [B1]
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2021 |
Morichetto H, Nilsson M, 'Can residential architecture constitute a part of a human-enriched environment and contribute to recovery, prevention and stress reduction?', Architecture for Residential Care and Ageing Communities: Spaces for Dwelling and Healthcare, Routledge, New York, NY 53-64 (2021) [B1]
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2018 |
Janssen H, Nilsson M, Spratt N, Walker FR, Pollack M, 'Environmental enrichment:neurophysiological responses and consequences for health', The Oxford Textbook of Nature and Public Health - The role of nature in improving the health of a population, Oxford University Press, Great Britain 71-78 (2018)
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2016 |
Walker FR, Ong L, Nilsson M, 'Chronic Stress-induced Changes in Microglia in Determining Vulnerability to Mood Disorders', PRIMER OF PSYCHONEUROIMMUNOLOGY RESEARCH, PsychoNeuroImmunology Research Society, Los Angeles, CA 119-124 (2016) [B1]
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Journal article (233 outputs)
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2024 |
Sopasakis A, Nilsson M, Askenmo M, Nyholm F, Mattsson Hultén L, Rotter Sopasakis V, 'Machine learning evaluation for identification of M-proteins in human serum.', PLoS One, 19 e0299600 (2024) [C1]
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2023 |
Hinwood M, Ilicic M, Gyawali P, Coupland K, Kluge MG, Smith A, et al., 'Psychological Stress Management and Stress Reduction Strategies for Stroke Survivors: A Scoping Review', Annals of behavioral medicine : a publication of the Society of Behavioral Medicine, 57 111-130 (2023) [C1] BACKGROUND: Stroke can be a life-changing event, with survivors frequently experiencing some level of disability, reduced independence, and an abrupt lifestyle change. Not surpris... [more] BACKGROUND: Stroke can be a life-changing event, with survivors frequently experiencing some level of disability, reduced independence, and an abrupt lifestyle change. Not surprisingly, many stroke survivors report elevated levels of stress during the recovery process, which has been associated with worse outcomes. PURPOSE: Given the multiple roles of stress in the etiology of stroke recovery outcomes, we aimed to scope the existing literature on stress management interventions that have been trialed in stroke survivors. METHODS: We performed a database search for intervention studies conducted in stroke survivors which reported the effects on stress, resilience, or coping outcome. Medline (OVID), Embase (OVID), CINAHL (EBSCO), Cochrane Library, and PsycInfo (OVID) were searched from database inception until March 11, 2019, and updated on September 1, 2020. RESULTS: Twenty-four studies met the inclusion criteria. There was significant variation in the range of trialed interventions, as well as the outcome measures used to assess stress. Overall, just over half (13/24) of the included studies reported a benefit in terms of stress reduction. Acceptability and feasibility were considered in 71% (17/24) and costs were considered in 17% (4/24) of studies. The management of stress was rarely linked to the prevention of symptoms of stress-related disorders. The overall evidence base of included studies is weak. However, an increase in the number of studies over time suggests a growing interest in this subject. CONCLUSIONS: Further research is required to identify optimum stress management interventions in stroke survivors, including whether the management of stress can ameliorate the negative impacts of stress on health.
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2023 |
Hood RJ, Sanchez-Bezanilla S, Beard DJ, Rust R, Turner RJ, Stuckey SM, et al., 'Leakage beyond the primary lesion: A temporal analysis of cerebrovascular dysregulation at sites of hippocampal secondary neurodegeneration following cortical photothrombotic stroke', Journal of Neurochemistry, 167 733-752 (2023) [C1] We have previously demonstrated that a cortical stroke causes persistent impairment of hippocampal-dependent cognitive tasks concomitant with secondary neurodegenerative processes... [more] We have previously demonstrated that a cortical stroke causes persistent impairment of hippocampal-dependent cognitive tasks concomitant with secondary neurodegenerative processes such as amyloid-ß accumulation in the hippocampus, a region remote from the primary infarct. Interestingly, there is emerging evidence suggesting that deposition of amyloid-ß around cerebral vessels may lead to cerebrovascular structural changes, neurovascular dysfunction, and disruption of blood¿brain barrier integrity. However, there is limited knowledge about the temporal changes of hippocampal cerebrovasculature after cortical stroke. In the current study, we aimed to characterise the spatiotemporal cerebrovascular changes after cortical stroke. This was done using the photothrombotic stroke model targeting the motor and somatosensory cortices of mice. Cerebrovascular morphology as well as the co-localisation of amyloid-ß with vasculature and blood¿brain barrier integrity were assessed in the cortex and hippocampal regions at 7, 28 and 84 days post-stroke. Our findings showed transient cerebrovascular remodelling in the peri-infarct area up to 28 days post-stroke. Importantly, the cerebrovascular changes were extended beyond the peri-infarct region to the ipsilateral hippocampus and were sustained out to 84 days post-stroke. When investigating vessel diameter, we showed a decrease at 84 days in the peri-infarct and CA1 regions that were exacerbated in vessels with amyloid-ß deposition. Lastly, we showed sustained vascular leakage in the peri-infarct and ipsilateral hippocampus, indicative of a compromised blood¿brain-barrier. Our findings indicate that hippocampal vasculature may represent an important therapeutic target to mitigate the progression of post-stroke cognitive impairment.
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2023 |
Paul M, Paul JW, Hinwood M, Hood RJ, Martin K, Abdolhoseini M, et al., 'Clopidogrel Administration Impairs Post-Stroke Learning and Memory Recovery in Mice', International Journal of Molecular Sciences, 24 11706-11706 [C1]
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2023 |
Ramanathan S, Lynch E, Bernhardt J, Nilsson M, Cadilhac DA, Carey L, et al., 'Impact assessment of the Centre for Research Excellence in Stroke Rehabilitation and Brain Recovery.', Health research policy and systems, 21 30 (2023) [C1]
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2023 |
Galloway M, Marsden DL, Callister R, Erickson KI, Nilsson M, English C, 'How little is enough? The feasibility of conducting a dose-escalation study for exercise training in people with stroke.', J Stroke Cerebrovasc Dis, 32 107190 (2023) [C1]
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2023 |
Ditton E, Knott B, Hodyl N, Horton G, Oldmeadow C, Walker FR, Nilsson M, 'Evaluation of an App-Delivered Psychological Flexibility Skill Training Intervention for Medical Student Burnout and Well-being: Randomized Controlled Trial.', JMIR Ment Health, 10 e42566 (2023) [C1]
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2023 |
Ditton E, Knott B, Hodyl N, Horton G, Walker FR, Nilsson M, 'Medical Student Experiences of Engaging in a Psychological Flexibility Skill Training App for Burnout and Well-being: Pilot Feasibility Study.', JMIR Form Res, 7 e43263 (2023) [C1]
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2023 |
Deeming S, Hure A, Attia J, Nilsson M, Searles A, 'Prioritising and incentivising productivity within indicator-based approaches to Research Impact Assessment: a commentary.', Health Res Policy Syst, 21 136 (2023) [C1]
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2022 |
Valkenborghs SR, Hillman CH, Al-Iedani O, Nilsson M, Smith JJ, Leahy AA, et al., 'Effect of high-intensity interval training on hippocampal metabolism in older adolescents', PSYCHOPHYSIOLOGY, 59 (2022) [C1]
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2022 |
Sammut M, Haracz K, Shakespeare D, English C, Crowfoot G, Fini N, et al., 'Physical Activity After Transient Ischemic Attack or Mild Stroke Is Business as Usual', Journal of Neurologic Physical Therapy, 46 189-197 (2022) [C1] Background and Purpose: Regular, sustained moderate-to-vigorous physical activity (MVPA) is a recommended strategy to reduce the risk of recurrent stroke for people who have had t... [more] Background and Purpose: Regular, sustained moderate-to-vigorous physical activity (MVPA) is a recommended strategy to reduce the risk of recurrent stroke for people who have had transient ischemic attack (TIA) or mild stroke. This study aimed to explore attitudes toward, and experience of engaging in physical activity by adults following a TIA or mild stroke. Methods: Constructivist grounded theory methodology informed data collection and analysis. Interviews from 33 adults with TIA or mild stroke (mean age 65 [SD 10] years, 48% female, 40% TIA) were collected. Results: Business as usual characterized physical activity engagement post-TIA or mild stroke. Most participants returned to prestroke habits, as either regular exerciser or nonexerciser, with only a small number making changes. Influencing factors for physical activity participation included information, challenges, strategies, and support. Business as usual was associated with a perceived lack of information to suggest a need to change behaviors. Nonexercisers and those who decreased physical activity emphasized challenges to physical activity, while regular exercisers and those who increased physical activity focused on strategies and support that enabled participation despite challenges. Discussion and Conclusion: Information about the necessity to engage in recommended physical activity levels requires tailoring to the needs of the people with TIA or mild stroke. Helpful information in combination with support and strategies may guide how to navigate factors preventing engagement and might influence the low level of physical activity prevalent in this population. Video Abstract available for more insights from the authors (see the Video, Supplemental Digital Content 1 available at: Http://links.lww.com/JNPT/A376).
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2022 |
Sanchez-Bezanilla S, Beard DJ, Hood RJ, Åberg ND, Crock P, Walker FR, et al., 'Growth Hormone Increases BDNF and mTOR Expression in Specific Brain Regions after Photothrombotic Stroke in Mice.', Neural plasticity, 2022 9983042 (2022) [C1]
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2022 |
Janssen H, Ada L, Middleton S, Pollack M, Nilsson M, Churilov L, et al., 'Altering the rehabilitation environment to improve stroke survivor activity: A Phase II trial', International Journal of Stroke, 17 299-307 (2022) [C1] Background: Environmental enrichment involves organization of the environment and provision of equipment to facilitate engagement in physical, cognitive, and social activities. In... [more] Background: Environmental enrichment involves organization of the environment and provision of equipment to facilitate engagement in physical, cognitive, and social activities. In animals with stroke, it promotes brain plasticity and recovery. Aims: To assess the feasibility and safety of a patient-driven model of environmental enrichment incorporating access to communal and individual environmental enrichment. Methods: A nonrandomized cluster trial with blinded measurement involving people with stroke (n = 193) in four rehabilitation units was carried out. Feasibility was operationalized as activity 10 days after admission to rehabilitation and availability of environmental enrichment. Safety was measured as falls and serious adverse events. Benefit was measured as clinical outcomes at three months, by an assessor blinded to group. Results: The experimental group (n = 91) spent 7% (95% CI -14 to 0) less time inactive, 9% (95% CI 0¿19) more time physically, and 6% (95% CI 2¿10) more time socially active than the control group (n = 102). Communal environmental enrichment was available 100% of the time, but individual environmental enrichment was rarely within reach (24%) or sight (39%). There were no between-group differences in serious adverse events or falls at discharge or three months or in clinical outcomes at three months. Conclusions: This patient-driven model of environmental enrichment was feasible and safe. However, the very modest increase in activity by people with stroke, and the lack of benefit in clinical outcomes three months after stroke do not provide justification for an efficacy trial.
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2022 |
Sammut M, Fini N, Haracz K, Nilsson M, English C, Janssen H, 'Increasing time spent engaging in moderate-to-vigorous physical activity by community-dwelling adults following a transient ischemic attack or non-disabling stroke: a systematic review', Disability and Rehabilitation, 44 337-352 (2022) [C1] Purpose: The risk of recurrent stroke following a transient ischaemic attack (TIA) or non-disabling stroke is high. Clinical guidelines recommend this patient population accumulat... [more] Purpose: The risk of recurrent stroke following a transient ischaemic attack (TIA) or non-disabling stroke is high. Clinical guidelines recommend this patient population accumulate at least 150 minutes of moderate-to-vigorous physical activity each week to reduce the risk of recurrent stroke. We aimed to identify interventions that increase time adults spend in moderate-to-vigorous physical activity following TIA or non-disabling stroke. Method: We searched thirteen databases for articles of secondary prevention interventions reporting outcomes for duration in moderate-to-vigorous physical activity or exercise capacity. Results: Eight trials were identified (n = 2653). Of these, three (n = 198) reported changes in time spent in moderate-to-vigorous physical activity. Only one trial (n = 70), reported significant change in time spent engaging in moderate-to-vigorous physical activity (between-group difference: 11.7 min/day [95% CI 4.07¿19.33]) when comparing participation in a six-month exercise education intervention to usual care. No trial measured moderate-to-vigorous physical activity after intervention end. Conclusion: Despite recommendations to participate in regular physical activity at moderate-to-vigorous intensity for secondary stroke prevention, there is very little evidence for effective interventions for this patient population. There is need for clinically feasible interventions that result in long-term participation in physical activity in line with clinical guidelines. Trial registration: Protocol registration: PROSPERO CRD42018092840Implications for rehabilitation There is limited evidence of the effectiveness of interventions that aim to increase time spent engaging in moderate-to-vigorous physical activity (MVPA) for people following a TIA or non-disabling stroke. A program comprising aerobic and resistance exercises =2 per week, supervised by a health professional (supplemented with a home program) over at least 24 weeks appears to be effective in assisting people adhere to recommended levels of moderate to vigorous physical activity after TIA or non-disabling stroke. Secondary prevention programs which include health professional supervised exercise sessions contribute to better adherence to physical activity guidelines; didactic sessions alone outlining frequency and intensity are unlikely to be sufficient.
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2021 |
Zalewska K, Hood RJ, Pietrogrande G, Sanchez-Bezanilla S, Ong LK, Johnson SJ, et al., 'Corticosterone administration alters white matter tract structure and reduces gliosis in the sub-acute phase of experimental stroke', International Journal of Molecular Sciences, 22 (2021) [C1] White matter tract (WMT) degeneration has been reported to occur following a stroke, and it is associated with post-stroke functional disturbances. White matter pathology has been... [more] White matter tract (WMT) degeneration has been reported to occur following a stroke, and it is associated with post-stroke functional disturbances. White matter pathology has been suggested to be an independent predictor of post-stroke recovery. However, the factors that influence WMT remodeling are poorly understood. Cortisol is a steroid hormone released in response to prolonged stress, and elevated levels of cortisol have been reported to interfere with brain recovery. The objective of this study was to investigate the influence of corticosterone (CORT; the rodent equivalent of cortisol) on WMT structure post-stroke. Photothrombotic stroke (or sham surgery) was induced in 8-week-old male C57BL/6 mice. At 72 h, mice were exposed to standard drinking water ± CORT (100 µg/mL). After two weeks of CORT administration, mice were euthanised and brain tissue collected for histological and biochemical analysis of WMT (particularly the corpus cal-losum and corticospinal tract). CORT administration was associated with increased tissue loss within the ipsilateral hemisphere, and modest and inconsistent WMT reorganization. Further, a structural and molecular analysis of the WMT components suggested that CORT exerted effects over axons and glial cells. Our findings highlight that CORT at stress-like levels can moderately influence the reorganization and microstructure of WMT post-stroke.
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2021 |
Cochrane JA, Flynn T, Wills A, Walker FR, Nilsson M, Johnson SJ, 'Clinical Decision Support Tools for Predicting Outcomes in Patients Undergoing Total Knee Arthroplasty: A Systematic Review', JOURNAL OF ARTHROPLASTY, 36 1832-+ (2021) [C1]
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2021 |
Mosalski S, Shiner CT, Lannin NA, Cadilhac DA, Faux SG, Kim J, et al., 'Increased Relative Functional Gain and Improved Stroke Outcomes: A Linked Registry Study of the Impact of Rehabilitation', JOURNAL OF STROKE & CEREBROVASCULAR DISEASES, 30 (2021) [C1]
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2021 |
Weerasekara I, Baye J, Burke M, Crowfoot G, Mason G, Peak R, et al., 'What do stroke survivors' value about participating in research and what are the most important research problems related to stroke or transient ischemic attack (TIA)? A survey', BMC MEDICAL RESEARCH METHODOLOGY, 21 (2021) [C1]
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2021 |
Lubans DR, Smith JJ, Eather N, Leahy AA, Morgan PJ, Lonsdale C, et al., 'Time-efficient intervention to improve older adolescents' cardiorespiratory fitness: Findings from the a Burn 2 Learn' cluster randomised controlled trial', British Journal of Sports Medicine, 55 751-758 (2021) [C1] Background Cardiorespiratory fitness (CRF) is an important marker of current and future health status. The primary aim of our study was to evaluate the impact of a time-efficient ... [more] Background Cardiorespiratory fitness (CRF) is an important marker of current and future health status. The primary aim of our study was to evaluate the impact of a time-efficient school-based intervention on older adolescents' CRF. Methods Two-arm cluster randomised controlled trial conducted in two cohorts (February 2018 to February 2019 and February 2019 to February 2020) in New South Wales, Australia. Participants (N=670, 44.6% women, 16.0±0.43 years) from 20 secondary schools: 10 schools (337 participants) were randomised to the Burn 2 Learn (B2L) intervention and 10 schools (333 participants) to the control. Teachers in schools allocated to the B2L intervention were provided with training, resources, and support to facilitate the delivery of high-intensity interval training (HIIT) activity breaks during curriculum time. Teachers and students in the control group continued their usual practice. The primary outcome was CRF (20 m multi-stage fitness test). Secondary outcomes were muscular fitness, physical activity, hair cortisol concentrations, mental health and cognitive function. Outcomes were assessed at baseline, 6 months (primary end-point) and 12 months. Effects were estimated using mixed models accounting for clustering. Results We observed a group-by-time effect for CRF (difference=4.1 laps, 95% CI 1.8 to 6.4) at the primary end-point (6 months), but not at 12 months. At 6 months, group-by-time effects were found for muscular fitness, steps during school hours and cortisol. Conclusions Implementing HIIT during curricular time improved adolescents' CRF and several secondary outcomes. Our findings suggest B2L is unlikely to be an effective approach unless teachers embed sessions within the school day. Trial registration number Australian New Zealand Clinical Trials Registry (ACTRN12618000293268).
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2021 |
Sanchez-Bezanilla S, Hood RJ, Collins-Praino LE, Turner RJ, Walker FR, Nilsson M, Ong LK, 'More than motor impairment: A spatiotemporal analysis of cognitive impairment and associated neuropathological changes following cortical photothrombotic stroke', Journal of Cerebral Blood Flow and Metabolism, 41 2439-2455 (2021) [C1] There is emerging evidence suggesting that a cortical stroke can cause delayed and remote hippocampal dysregulation, leading to cognitive impairment. In this study, we aimed to in... [more] There is emerging evidence suggesting that a cortical stroke can cause delayed and remote hippocampal dysregulation, leading to cognitive impairment. In this study, we aimed to investigate motor and cognitive outcomes after experimental stroke, and their association with secondary neurodegenerative processes. Specifically, we used a photothrombotic stroke model targeting the motor and somatosensory cortices of mice. Motor function was assessed using the cylinder and grid walk tasks. Changes in cognition were assessed using a mouse touchscreen platform. Neuronal loss, gliosis and amyloid-ß accumulation were investigated in the peri-infarct and ipsilateral hippocampal regions at 7, 28 and 84 days post-stroke. Our findings showed persistent impairment in cognitive function post-stroke, whilst there was a modest spontaneous motor recovery over the investigated period of 84 days. In the peri-infarct region, we detected a reduction in neuronal loss and decreased neuroinflammation over time post-stroke, which potentially explains the spontaneous motor recovery. Conversely, we observed persistent neuronal loss together with concomitant increased neuroinflammation and amyloid-ß accumulation in the hippocampus, which likely accounts for the persistent cognitive dysfunction. Our findings indicate that cortical stroke induces secondary neurodegenerative processes in the hippocampus, a region remote from the primary infarct, potentially contributing to the progression of post-stroke cognitive impairment.
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2021 |
Zhao Z, Hood RJ, Ong LK, Pietrogrande G, Sanchez Bezanilla S, Warren KE, et al., 'Exploring How Low Oxygen Post Conditioning Improves Stroke-Induced Cognitive Impairment: A Consideration of Amyloid-Beta Loading and Other Mechanisms', FRONTIERS IN NEUROLOGY, 12 (2021) [C1]
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2021 |
Sammut M, Haracz K, English C, Shakespeare D, Crowfoot G, Nilsson M, Janssen H, 'Participants perspective of engaging in a gym-based health service delivered secondary stroke prevention program after tia or mild stroke', International Journal of Environmental Research and Public Health, 18 (2021) [C1] People who have had a transient ischemic attack (TIA) or mild stroke have a high risk of recurrent stroke. Secondary prevention programs providing support for meeting physical act... [more] People who have had a transient ischemic attack (TIA) or mild stroke have a high risk of recurrent stroke. Secondary prevention programs providing support for meeting physical activity recommendations may reduce this risk. Most evidence for the feasibility and effectiveness of secondary stroke prevention arises from programs developed and tested in research institute settings with limited evidence for the acceptability of programs in ¿real world¿ community settings. This qualitative descriptive study explored perceptions of participation in a secondary stroke prevention program (delivered by a community-based multidisciplinary health service team within a community gym) by adults with TIA or mild stroke. Data gathered via phone-based semi-structured interviews midway through the program, and at the end of the program, were analyzed using constructivist grounded theory methods. A total of 51 interviews from 30 participants produced two concepts. The first concept, ¿What it offered me¿, describes critical elements that shape participants¿ experience of the program. The second concept, ¿What I got out of it¿ describes perceived benefits of program participation. Participants perceived that experiences with peers in a health professional-led group program, held within a community-based gym, supported their goal of changing behaviour. Including these elements during the development of health service strategies to reduce recurrent stroke risk may strengthen program acceptability and subsequent effectiveness.
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2021 |
Koh C-L, Yeh C-H, Liang X, Vidyasagar R, Seitz RJ, Nilsson M, et al., 'Structural Connectivity Remote From Lesions Correlates With Somatosensory Outcome Poststroke', STROKE, 52 2910-2920 (2021) [C1]
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2021 |
Stokowska A, Bunketorp Kall L, Blomstrand C, Simren J, Nilsson M, Zetterberg H, et al., 'Plasma neurofilament light chain levels predict improvement in late phase after stroke', EUROPEAN JOURNAL OF NEUROLOGY, 28 2218-2228 (2021) [C1]
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2020 |
Sanchez-Bezanilla S, Aberg ND, Crock P, Walker FR, Nilsson M, Isgaard J, Ong LK, 'Growth Hormone Promotes Motor Function after Experimental Stroke and Enhances Recovery-Promoting Mechanisms within the Peri-Infarct Area', INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 21 (2020) [C1]
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2020 |
Sanchez-Bezanilla S, Aberg ND, Crock P, Walker FR, Nilsson M, Isgaard J, Ong LK, 'Growth Hormone Treatment Promotes Remote Hippocampal Plasticity after Experimental Cortical Stroke', INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 21 (2020) [C1]
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2020 |
Gyawali P, Hinwood M, Chow WZ, Kluge M, Ong LK, Nilsson M, Walker FR, 'Exploring the relationship between fatigue and circulating levels of the pro-inflammatory biomarkers interleukin-6 and C-reactive protein in the chronic stage of stroke recovery: A cross-sectional study', Brain, Behavior, & Immunity - Health, 9 (2020)
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2020 |
Bunketorp-Käll L, Pekna M, Pekny M, Samuelsson H, Blomstrand C, Nilsson M, 'Motor Function in the Late Phase After Stroke: Stroke Survivors' Perspective.', Annals of rehabilitation medicine, 44 362-369 (2020) [C1]
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2020 |
Chow WZ, Ong LK, Kluge MG, Gyawali P, Walker FR, Nilsson M, 'Similar cognitive deficits in mice and humans in the chronic phase post-stroke identified using the touchscreen-based paired-associate learning task', SCIENTIFIC REPORTS, 10 (2020) [C1]
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2020 |
Aberg ND, Gadd G, Aberg D, Hallgren P, Blomstrand C, Jood K, et al., 'Relationship between Levels of Pre-Stroke Physical Activity and Post-Stroke Serum Insulin-Like Growth Factor I', BIOMEDICINES, 8 (2020) [C1]
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2020 |
Åberg ND, Åberg D, Lagging C, Holmegaard L, Redfors P, Jood K, et al., 'Association between Levels of Serum Insulin-like Growth Factor i and Functional Recovery, Mortality, and Recurrent Stroke at a 7-year Follow-up', Experimental and Clinical Endocrinology and Diabetes, 128 303-310 (2020) [C1] Background The association of serum insulin-like growth factor I (s-IGF-I) with favorable outcome after ischemic stroke (IS) beyond 2 years is unknown. We investigated whether the... [more] Background The association of serum insulin-like growth factor I (s-IGF-I) with favorable outcome after ischemic stroke (IS) beyond 2 years is unknown. We investigated whether the levels of s-IGF-I 3 months post-stroke were associated with functional recovery up to 7 years after IS, considering also mortality and recurrent strokes. Methods Patients (N=324; 65% males; mean age, 55 years) with s-IGF-I levels assessed 3 months after the index IS were included from the Sahlgrenska Academy Study on Ischemic Stroke (SAHLSIS). The modified Rankin Scale (mRS) was used to evaluate outcomes at 3 months, 2 and 7 years after IS, and recovery was defined as an improvement, no change, or deterioration in the shifts of mRS score. Baseline stroke severity was determined using the National Institutes of Health Stroke Scale (NIHSS). Results The mRS score distributions were better in the above-median s-IGF-I group (>146.7 ng/ml). The s-IGF-I level was not associated with recurrent stroke (N=79) or death (N=44), although it correlated with recovery (r=0.12, P=0.035). In the regression analysis, s-IGF-I associated with recovery between 3 months and 7 years (but not between 2 and 7 years). The associations did not withstand adjustment for age and sex. For comparison, the corresponding associations between 3 months and 2 years withstood all adjustments. Conclusion The association for s-IGF-I with long-term post-stroke recovery persists after 7 years, which is also reflected in the mRS score distributions at all time-points. The effects are however modest, and not driven by mortality or recurrent stroke.
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2020 |
Gyawali P, Chow WZ, Hinwood M, Kluge M, English C, Ong LK, et al., 'Opposing Associations of Stress and Resilience With Functional Outcomes in Stroke Survivors in the Chronic Phase of Stroke: A Cross-Sectional Study', FRONTIERS IN NEUROLOGY, 11 (2020) [C1]
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2020 |
Ditton E, Johnson S, Hodyl N, Flynn T, Pollack M, Ribbons K, et al., 'Improving Patient Outcomes Following Total Knee Arthroplasty: Identifying Rehabilitation Pathways Based on Modifiable Psychological Risk and Resilience Factors', Frontiers in Psychology, 11 (2020) [C1]
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2019 |
Bunketorp-Käll L, Pekna M, Pekny M, Blomstrand C, Nilsson M, 'Effects of horse-riding therapy and rhythm and music-based therapy on functional mobility in late phase after stroke', NeuroRehabilitation, 45 483-492 (2019) [C1] BACKGROUND: Persons with stroke commonly have residual neurological deficits that seriously hamper mobility. OBJECTIVE: To investigate whether horse-riding therapy (H-RT) and rhyt... [more] BACKGROUND: Persons with stroke commonly have residual neurological deficits that seriously hamper mobility. OBJECTIVE: To investigate whether horse-riding therapy (H-RT) and rhythm and music-based therapy (R-MT) affect functional mobility in late phase after stroke. METHODS: This study is part of a randomized controlled trial in which H-RT and R-MT was provided twice weekly for 12 weeks. Assessment included the timed 10-meter walk test (10 mWT), the six-minute walk test (6 MWT) and Modified Motor Assessment Scale (M-MAS). RESULTS: 123 participants were assigned to H-RT (n = 41), R-MT (n = 41), or control (n = 41). Post-intervention, the H-RT group completed the 10 mWT faster at both self-selected (-2.22 seconds [95% CI,-3.55 to-0.88]; p = 0.001) and fast speed (-1.19 seconds [95% CI,-2.18 to-0.18]; p = 0.003), with fewer steps (-2.17 [95% CI,-3.30 to-1.04]; p = 0.002 and-1.40 [95% CI,-2.36 to-0.44]; p = 0.020, respectively), as compared to controls. The H-RT group also showed improvements in functional task performance as measured by M-MAS UAS (1.13 [95% CI, 0.74 to 1.52]; p = 0.001). The gains were partly maintained at 6 months among H-RT participants. The R-MT did not produce any immediate gains. However, 6 months post-intervention, the R-MT group performed better with respect to time;-0.75 seconds [95% CI,-1.36 to-0.14]; p = 0.035) and number of steps-0.76 [95% CI,-1.46 to-0.05]; p = 0.015) in the 10 mWT at self-selected speed. CONCLUSIONS: The present study supports the efficacy of H-RT in producing immediate gains in gait and functional task performance in the late phase after stroke, whereas the effectiveness of R-MT is less clear.
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2019 |
Gopaul U, van Vliet P, Callister R, Nilsson M, Carey L, 'COMbined Physical and somatoSEnsory training after stroke: Development and description of a novel intervention to improve upper limb function', Physiotherapy Research International, 24 1-12 (2019) [C1]
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2019 |
Galloway M, Marsden DL, Callister R, Erickson KI, Nilsson M, English C, 'What is the dose-response relationship between exercise and cardiorespiratory fitness after stroke? A systematic review', Physical Therapy, 99 821-832 (2019) [C1] Background. Exercise after stroke improves cardiorespiratory fitness and walking capacity; however, the effect of altering exercise dose (via frequency, intensity, time, and type)... [more] Background. Exercise after stroke improves cardiorespiratory fitness and walking capacity; however, the effect of altering exercise dose (via frequency, intensity, time, and type) on fitness or walking capacity is unclear. Purpose. The purpose of this study was to synthesize the current evidence for the effects of different doses of exercise on cardiorespiratory fitness and walking capacity in people after stroke. Data Sources. Seven relevant electronic databases were searched using keywords relating to stroke and cardiorespiratory fitness. Study Selection. Trials that compared more than 1 dose of exercise for people (? 18 years old) after stroke and measured peak oxygen consumption or 6-minute walk test distance as an outcome were included. Two reviewers independently appraised all trials. Data Extraction. Two reviewers independently extracted data from included articles. Intervention variables were extracted in accordance with the Template for Intervention Description and Replication checklist. Data Synthesis. Data were synthesized narratively. Nine trials involving 279 participants were included. Three of 5 trials comparing exercise intensity showed that higherintensity training was associated with greater improvements in cardiorespiratory fitness. The effects of other exercise dose components (frequency, time, and type) on fitness were not determined. Overall, walking capacity improved as program length increased. Limitations. All trials had a high risk of bias, and most had a high rate of attrition. Most trials included people more than 6 months after stroke and who walked independently, limiting the generalizability of the findings. Conclusions. Exercising at an intensity greater than 70% of heart rate reserve can be more effective in increasing cardiorespiratory fitness after stroke than exercising at lower intensities. More trials that compare exercise doses by manipulating only 1 dose parameter at a time for people after stroke are needed.
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2019 |
Valkenborghs SR, Callister R, Visser MM, Nilsson M, van Vliet P, 'Interventions combined with task-specific training to improve upper limb motor recovery following stroke: a systematic review with meta-analyses', Physical Therapy Reviews, 24 1-19 (2019) [C1]
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2019 |
Sanchez-Bezanilla S, TeBay C, Nilsson M, Walker FR, Ong LK, 'Visual discrimination impairment after experimental stroke is associated with disturbances in the polarization of the astrocytic aquaporin-4 and increased accumulation of neurotoxic proteins', Experimental Neurology, 318 232-243 (2019) [C1] Numerous clinical studies have documented the high incidence of cognitive impairment after stroke. However, there is only limited knowledge about the underlying mechanisms. Intere... [more] Numerous clinical studies have documented the high incidence of cognitive impairment after stroke. However, there is only limited knowledge about the underlying mechanisms. Interestingly, there is emerging evidence suggesting that cognitive function after stroke may be affected due to reduced waste clearance and subsequent accumulation of neurotoxic proteins. To further explore this potential association, we utilised a model of experimental stroke in mice. Specifically, a photothrombotic vascular occlusion targeting motor and sensory parts of the cerebral cortex was induced in young adult mice, and changes in cognition were assessed using a touchscreen platform for pairwise visual discrimination. The results showed that the execution of the visual discrimination task was impaired in mice 10 to 14 days post-stroke compared to sham. Stroke also induced significant neuronal loss within the peri-infarct, thalamus and the CA1 sub-region of the hippocampus. Further, immunohistochemical and protein analyses of the selected brain regions revealed an increased accumulation and aggregation of both amyloid-ß and a-synuclein. These alterations were associated with significant disturbances in the aquaporin-4 protein expression and polarization at the astrocytic end-feet. The results suggest a link between the increased accumulation of neurotoxic proteins and the stroke-induced cognitive impairment. Given that the neurotoxic protein accumulation appeared alongside changes in astrocytic aquaporin-4 distribution, we suggest that the function of the waste clearance pathways in the brain post-stroke may represent a therapeutic target to improve brain recovery.
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2019 |
Leahy AA, Eather N, Smith JJ, Hillman CH, Morgan PJ, Plotnikoff RC, et al., 'Feasibility and Preliminary Efficacy of a Teacher-Facilitated High-Intensity Interval Training Intervention for Older Adolescents.', Pediatr Exerc Sci, 31 107-117 (2019) [C1]
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2019 |
Gallowayphd M, Marsden DL, Callister R, Nilsson M, Erickson KI, English C, 'The feasibility of a telehealth exercise program aimed at increasing cardiorespiratory fitness for people after stroke', International Journal of Telerehabilitation, 11 9-28 (2019) [C1] Background: Accessing suitable fitness programs post-stroke is difficult for many. The feasibility of telehealth delivery has not been previously reported. Objectives: To assess t... [more] Background: Accessing suitable fitness programs post-stroke is difficult for many. The feasibility of telehealth delivery has not been previously reported. Objectives: To assess the feasibility of, and level of satisfaction with home-based telehealth-supervised aerobic exercise training post-stroke. Methods: Twenty-one ambulant participants (= 3 months post-stroke) participated in a home-based telehealth-supervised aerobic exercise program (3 d/week, moderate-vigorous intensity, 8-weeks) and provided feedback via questionnaire post-intervention. Session details, technical issues, and adverse events were also recorded. Results: Feasibility was high (83% of volunteers met telehealth eligibility criteria, 85% of sessions were conducted by telehealth, and 95% of participants rated usability favourably). Ninety-five percent enjoyed telehealth exercise sessions and would recommend them to others. The preferred telehealth exercise program parameters were: frequency 3 d/week, duration 20-30 min/session, program length 6-12 weeks. Conclusion: The telehealth delivery of exercise sessions to people after stroke appears feasible and may be considered as a viable alternative delivery means for providing supervised exercise post-stroke.
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2019 |
Valkenborghs SR, Erickson KI, Nilsson M, van Vliet P, Callister R, 'Feasibility of Aerobic Interval Training in Nonambulant Persons after Stroke', Journal of Clinical Exercise Physiology, 8 97-101 (2019) [C1]
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2019 |
Carey L, Walsh A, Adikari A, Goodin P, Alahakoon D, De Silva D, et al., 'Finding the Intersection of Neuroplasticity, Stroke Recovery, and Learning: Scope and Contributions to Stroke Rehabilitation', Neural Plasticity, 2019 (2019) [C1]
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2019 |
Pietrogrande G, Zalewska K, Zhao Z, Abdolhoseini M, Chow WZ, Sanchez-Bezanilla S, et al., 'Low oxygen post conditioning prevents thalamic secondary neuronal loss caused by excitotoxicity after cortical stroke', SCIENTIFIC REPORTS, 9 (2019) [C1]
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2019 |
Sanchez-Bezanilla S, Nilsson M, Walker FR, Ong LK, 'Can We Use 2,3,5-Triphenyltetrazolium Chloride-Stained Brain Slices for Other Purposes? The Application of Western Blotting', FRONTIERS IN MOLECULAR NEUROSCIENCE, 12 (2019) [C1]
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2019 |
Valkenborghs SR, van Vliet P, Nilsson M, Zalewska K, Visser MM, Erickson KI, Callister R, 'Aerobic exercise and consecutive task-specific training (AExaCTT) for upper limb recovery after stroke: A randomized controlled pilot study', Physiotherapy Research International, 24 1-11 (2019) [C1]
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2019 |
Valkenborghs SR, Noetel M, Hillman C, Nilsson M, Smith J, Ortega F, Lubans DR, 'The Impact of Physical Activity on Brain Structure and Function in Youth: A Systematic Review', PEDIATRICS, 144 (2019) [C1]
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2019 |
Pietrogrande G, Zalewska K, Zhao Z, Johnson SJ, Nilsson M, Walker FR, 'Low Oxygen Post Conditioning as an Efficient Non-pharmacological Strategy to Promote Motor Function After Stroke', Translational Stroke Research, 10 402-412 (2019) [C1]
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2019 |
Kluge MG, Abdolhoseini M, Zalewska K, Ong LK, Johnson SJ, Nilsson M, Walker FR, 'Spatiotemporal analysis of impaired microglia process movement at sites of secondary neurodegeneration post-stroke', JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 39 2456-2470 (2019) [C1]
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2018 |
Mayhew J, Graham BA, Biber K, Nilsson M, Walker FR, 'Purinergic modulation of glutamate transmission: An expanding role in stress-linked neuropathology.', Neuroscience and biobehavioral reviews, 93 26-37 (2018) [C1]
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2018 |
Lynch EA, Ramanathan SA, Middleton S, Bernhardt J, Nilsson M, Cadilhac DA, 'A mixed-methods study to explore opinions of research translation held by researchers working in a Centre of Research Excellence in Australia.', BMJ open, 8 (2018) [C1]
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2018 |
Pohl P, Carlsson G, Käll LB, Nilsson M, Blomstrand C, 'A qualitative exploration of post-acute stroke participants experiences of a multimodal intervention incorporating horseback riding', PLoS ONE, 13 (2018) [C1]
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2018 |
Lillicrap T, Garcia-Esperon C, Walker FR, Ong LK, Nilsson M, Spratt N, et al., 'Growth Hormone Deficiency Is Frequent After Recent Stroke', FRONTIERS IN NEUROLOGY, 9 (2018) [C1]
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2018 |
Pohl P, Carlsson G, Bunketorp Käll L, Nilsson M, Blomstrand C, 'Experiences from a multimodal rhythm and music-based rehabilitation program in late phase of stroke recovery - A qualitative study.', PloS one, 13 (2018) [C1]
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2018 |
Wallin A, Kettunen P, Johansson PM, Jonsdottir IH, Nilsson C, Nilsson M, et al., 'Cognitive medicine - a new approach in health care science', BMC Psychiatry, 18 (2018) [C1]
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2018 |
Pietrogrande G, Mabotuwana N, Zhao Z, Abdolhoseini M, Johnson SJ, Nilsson M, Walker FR, 'Chronic stress induced disturbances in Laminin: A significant contributor to modulating microglial pro-inflammatory tone?', BRAIN BEHAVIOR AND IMMUNITY, 68 23-33 (2018) [C1]
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2018 |
Deeming S, Reeves P, Ramanathan S, Attia J, Nilsson M, Searles A, 'Measuring research impact in medical research institutes: a qualitative study of the attitudes and opinions of Australian medical research institutes towards research impact assessment frameworks.', Health research policy and systems, 16 28 (2018) [C1]
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2018 |
Jones KA, Maltby S, Plank MW, Kluge M, Nilsson M, Foster PS, Walker FR, 'Peripheral immune cells infiltrate into sites of secondary neurodegeneration after ischemic stroke', Brain, Behavior, and Immunity, 67 299-307 (2018) [C1] Experimental stroke leads to microglia activation and progressive neuronal loss at sites of secondary neurodegeneration (SND). These lesions are remote from, but synaptically conn... [more] Experimental stroke leads to microglia activation and progressive neuronal loss at sites of secondary neurodegeneration (SND). These lesions are remote from, but synaptically connected to, primary infarction sites. Previous studies have demonstrated that immune cells are present in sites of infarction in the first hours and days after stroke, and are associated with increased neurodegeneration in peri-infarct regions. However, it is not known whether immune cells are also present in more distal sites where SND occurs. Our study aimed to investigate whether immune cells are present in sites of SND and, if so, how these cell populations compare to those in the peri-infarct zone. Cells were isolated from the thalamus, the main site of SND, and remaining brain tissue 14 days post-stroke. Analysis was performed using flow cytometry to quantify microglia, myeloid cell and lymphocyte numbers. We identified a substantial infiltration of immune cells in the ipsilateral (stroked) compared to the contralateral (control) thalamus, with a significant increase in the percentage of CD4+ and CD8+ T cells. This result was further quantified using immunofluorescent labelling of fixed tissue. In the remaining ipsilateral hemisphere tissue, there were significant increases in the frequency of CD4+ and CD8+ T lymphocytes, B lymphocytes, Ly6G+ neutrophils and both Ly6G-Ly6CLO and Ly6G-Ly6CHI monocytes. Our results indicate that infiltrating immune cells persist in ischemic tissue after the acute ischemic phase, and are increased in sites of SND. Importantly, immune cells have been shown to play pivotal roles in both damage and repair processes after stroke. Our findings indicate that immune cells may also be involved in the pathogenesis of SND and further clinical studies are warranted to characterise the nature of inflammatory cell infiltrates in human disease.
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2018 |
Gopaul U, Carey L, Callister R, Nilsson M, van Vliet P, 'Combined somatosensory and motor training to improve upper limb function following stroke: a systematic scoping review', Physical Therapy Reviews, 23 355-375 (2018) [C1] Purpose: The purpose of this systematic scoping review was to (1) identify combined somatosensory and motor training interventions for the upper limb and their training components... [more] Purpose: The purpose of this systematic scoping review was to (1) identify combined somatosensory and motor training interventions for the upper limb and their training components, and (2) review the efficacy of the combined interventions. Methods: Participants were adults post-stroke with somatosensory and/or movement deficits in the upper limb. All studies with interventions combining somatosensory and motor training and targeting the affected upper limb were included. Outcome measures were assessments of somatosensory and/or motor impairment and upper limb function. Results: Ten studies (n = 219) were included, comprising three randomized controlled trials, two pre-post studies with non-randomized comparison groups, three single-case experimental studies, and two case reports. There was heterogeneity across studies with regards to intervention contents and dosage, participant characteristics, and outcome measures. The interventions included combinations of tactile stimulation/discrimination, proprioceptive stimulation/discrimination, haptic object discrimination/recognition, movement training, and functional training. Only one group study, a non-randomized controlled study with multiple active components and the largest dose of treatment, found significant improvements in fine motor and somatosensory measures. Some improvements were found in case studies. Conclusion: There was little consistency across ¿combined somatosensory and motor training¿ interventions and few have been rigorously tested for efficacy across somatosensory, motor and functional outcomes.
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2018 |
Ong LK, Chow WZ, Tebay C, Kluge M, Pietrogrande G, Zalewska K, et al., 'Growth Hormone Improves Cognitive Function After Experimental Stroke', STROKE, 49 1257-+ (2018) [C1]
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2018 |
Bunketorp-Kall L, Lundgren-Nilsson A, Nilsson M, Blomstrand C, 'Multimodal rehabilitation in the late phase after stroke enhances the life situation of informal caregivers', TOPICS IN STROKE REHABILITATION, 25 161-167 (2018) [C1]
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2018 |
Valkenborghs SR, Visser MM, Nilsson M, Callister R, van Vliet P, 'Aerobic exercise prior to task-specific training to improve poststroke motor function: A case series.', Physiotherapy research international : the journal for researchers and clinicians in physical therapy, 23 e1707 (2018) [C1]
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2018 |
Kluge MG, Jones K, Kooi Ong L, Gowing EK, Nilsson M, Clarkson AN, Walker FR, 'Age-dependent Disturbances of Neuronal and Glial Protein Expression Profiles in Areas of Secondary Neurodegeneration Post-stroke', Neuroscience, 393 185-195 (2018) [C1] Despite the fact that approximately 80% of strokes occur in those aged over 60 years, many pre-clinical stroke studies have been conducted in younger adult rodents, raising debate... [more] Despite the fact that approximately 80% of strokes occur in those aged over 60 years, many pre-clinical stroke studies have been conducted in younger adult rodents, raising debate about translation and generalizability of these results. We were interested in potential age differences in stroke-induced secondary neurodegeneration (SND). SND involves the death of neurons in areas remote from, but connected to, the site of infarction, as well as glial disturbances. Here we investigated potential differences in key parameters of SND in the thalamus, a major site of post-stroke SND. Protein expression profiles in young adult (2¿4 months) and aged (22¿23 months) mice were analyzed 28 days after a cortical stroke. Our results show that age reduced the expression of synaptic markers (PSD 95, Synapsin1) and increased Amyloid ß oligomer accumulation after stroke. Protein expression of several markers of glial activity remained relatively stable across age groups post-stroke. We have identified that age exacerbates the severity of SND after stroke. Our results, however, do not support a view that microglia or astrocytes are the main contributors to the enhanced severity of SND in aged mice.
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2018 |
Zalewska K, Pietrogrande G, Ong LK, Abdolhoseini M, Kluge M, Johnson SJ, et al., 'Sustained administration of corticosterone at stress-like levels after stroke suppressed glial reactivity at sites of thalamic secondary neurodegeneration', Brain, Behavior, and Immunity, 69 210-222 (2018) [C1] Secondary neurodegeneration (SND) is an insidious and progressive condition involving the death of neurons in regions of the brain that were connected to but undamaged by the init... [more] Secondary neurodegeneration (SND) is an insidious and progressive condition involving the death of neurons in regions of the brain that were connected to but undamaged by the initial stroke. Our group have published compelling evidence that exposure to psychological stress can significantly exacerbate the severity SND, a finding that has considerable clinical implications given that stroke-survivors often report experiencing high and unremitting levels of psychological stress. It may be possible to use one or more targeted pharmacological approaches to limit the negative effects of stress on the recovery process but in order to move forward with this approach the most critical stress signals have to be identified. Accordingly, in the current study we have directed our attention to examining the potential effects of corticosterone, delivered orally at stress-like levels. Our interest is to determine how similar the effects of corticosterone are to stress on repair and remodelling that is known to occur after stroke. The study involved 4 groups, sham and stroke, either administered corticosterone or normal drinking water. The functional impact was assessed using the cylinder task for paw asymmetry, grid walk for sensorimotor function, inverted grid for muscle strength and coordination and open field for anxiety-like behaviour. Biochemically and histologically, we considered disturbances in main cellular elements of the neurovascular unit, including microglia, astrocytes, neurons and blood vessels using both immunohistochemistry and western blotting. In short, we identified that corticosterone delivery after stroke results in significant suppression of key microglial and astroglial markers. No changes were observed on the vasculature and in neuronal specific markers. No changes were identified for sensorimotor function or anxiety-like behaviour. We did, however, observe a significant change in motor function as assessed using the inverted grid walk test. Collectively, these results suggest that pharmacologically targeting corticosterone levels in the future may be warranted but that such an approach is unlikely to limit all the negative effects associated with exposure to chronic stress.
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2018 |
Åberg ND, Åberg D, Jood K, Nilsson M, Blomstrand C, Kuhn HG, et al., 'Altered levels of circulating insulin-like growth factor I (IGF-I) following ischemic stroke are associated with outcome - a prospective observational study.', BMC neurology, 18 (2018) [C1]
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2017 |
Bivard A, Lillicrap T, Krishnamurthy V, Holliday E, Attia J, Pagram H, et al., 'MIDAS (Modafinil in Debilitating Fatigue after Stroke): A Randomized, Double-Blind, Placebo-Controlled, Cross-Over Trial', Stroke, 48 1293-1298 (2017) [C1] Background and Purpose - This study aimed to assess the efficacy of modafinil, a wakefulness-promoting agent in alleviating post-stroke fatigue =3 months after stroke. We hypothes... [more] Background and Purpose - This study aimed to assess the efficacy of modafinil, a wakefulness-promoting agent in alleviating post-stroke fatigue =3 months after stroke. We hypothesized that 200 mg of modafinil daily for 6 weeks would result in reduced symptoms of fatigue compared with placebo. Methods - This single-center phase 2 trial used a randomized, double-blind, placebo-controlled, crossover design. The key inclusion criterion was a multidimensional fatigue inventory score of =60. Patients were randomized to either modafinil or placebo for 6 weeks of therapy, then after a 1 week washout period swapped treatment arms for a second 6 weeks of therapy. The primary outcome was the multidimensional fatigue inventory; secondary outcomes included the Montreal cognitive assessment, the Depression, Anxiety, and Stress Scale (DASS), and the Stroke-Specific Quality of Life (SSQoL) scale. The multidimensional fatigue inventory is a self-administered questionnaire with a range of 0 to 100. Treatment efficacy was assessed using linear regression by estimating within-person, baseline-adjusted differences in mean outcomes after therapy. This trial was registered with the Australian New Zealand Clinical Trials Registry (ACTRN12615000350527). Results - A total of 232 stroke survivors were screened and 36 were randomized. Participants receiving modafinil reported a significant decrease in fatigue (multidimensional fatigue inventory, -7.38; 95% CI, -21.76 to -2.99; P<0.001) and improved quality of life (SSQoL, 11.81; 95% CI, 2.31 to 21.31; P=0.0148) compared with placebo. Montreal cognitive assessment and DASS were not significantly improved with modafinil therapy during the study period (P>0.05). Conclusions - Stroke survivors with nonresolving fatigue reported reduced fatigue and improved quality of life after taking 200 mg daily treatment with modafinil.
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2017 |
Ong LK, Walker FR, Nilsson M, 'Is Stroke a Neurodegenerative Condition? A Critical Review of Secondary Neurodegeneration and Amyloid-beta Accumulation after Stroke', AIMS MEDICAL SCIENCE, 4 1-16 (2017) [C1]
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2017 |
Bunketorp-Käll L, Lundgren-Nilsson Å, Samuelsson H, Pekny T, Blomvé K, Pekna M, et al., 'Long-Term Improvements after Multimodal Rehabilitation in Late Phase after Stroke', Stroke, 48 1916-1924 (2017) [C1] Background and Purpose - Treatments that improve function in late phase after stroke are urgently needed. We assessed whether multimodal interventions based on rhythm-and-music th... [more] Background and Purpose - Treatments that improve function in late phase after stroke are urgently needed. We assessed whether multimodal interventions based on rhythm-and-music therapy or horse-riding therapy could lead to increased perceived recovery and functional improvement in a mixed population of individuals in late phase after stroke. Methods - Participants were assigned to rhythm-and-music therapy, horse-riding therapy, or control using concealed randomization, stratified with respect to sex and stroke laterality. Therapy was given twice a week for 12 weeks. The primary outcome was change in participants' perception of stroke recovery as assessed by the Stroke Impact Scale with an intention-to-treat analysis. Secondary objective outcome measures were changes in balance, gait, grip strength, and cognition. Blinded assessments were performed at baseline, postintervention, and at 3- and 6-month follow-up. Results - One hundred twenty-three participants were assigned to rhythm-and-music therapy (n=41), horse-riding therapy (n=41), or control (n=41). Post-intervention, the perception of stroke recovery (mean change from baseline on a scale ranging from 1 to 100) was higher among rhythm-and-music therapy (5.2 [95% confidence interval, 0.79-9.61]) and horse-riding therapy participants (9.8 [95% confidence interval, 6.00-13.66]), compared with controls (-0.5 [-3.20 to 2.28]); P=0.001 (1-way ANOVA). The improvements were sustained in both intervention groups 6 months later, and corresponding gains were observed for the secondary outcomes. Conclusions - Multimodal interventions can improve long-term perception of recovery, as well as balance, gait, grip strength, and working memory in a mixed population of individuals in late phase after stroke. Clinical Trial Registration - URL: http//www.ClinicalTrials.gov. Unique identifier: NCT01372059.
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2017 |
Corbett D, Carmichael ST, Murphy TH, Jones TA, Schwab ME, Jolkkonen J, et al., 'Enhancing the alignment of the preclinical and clinical stroke recovery research pipeline: Consensus-based core recommendations from the Stroke Recovery and Rehabilitation Roundtable translational working group', International Journal of Stroke, 12 462-471 (2017) [C1] Stroke recovery research involves distinct biological and clinical targets compared to the study of acute stroke. Guidelines are proposed for the pre-clinical modeling of stroke r... [more] Stroke recovery research involves distinct biological and clinical targets compared to the study of acute stroke. Guidelines are proposed for the pre-clinical modeling of stroke recovery and for the alignment of pre-clinical studies to clinical trials in stroke recovery.
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2017 |
Ong LK, Zhao Z, Kluge M, Walker FR, Nilsson M, 'Chronic stress exposure following photothrombotic stroke is associated with increased levels of amyloid beta accumulation and altered oligomerisation at sites of thalamic secondary neurodegeneration in mice', Journal of Cerebral Blood Flow and Metabolism, 37 1338-1348 (2017) [C1] Exposure to severe stress following stroke is recognised to complicate the recovery process. We have identified that stress can exacerbate the severity of post-stroke secondary ne... [more] Exposure to severe stress following stroke is recognised to complicate the recovery process. We have identified that stress can exacerbate the severity of post-stroke secondary neurodegeneration in the thalamus. In this study, we investigated whether exposure to stress could influence the accumulation of the neurotoxic protein Amyloid-b. Using an experimental model of focal cortical ischemia in adult mice combined with exposure to chronic restraint stress, we examined changes within the contra-and ipsilateral thalamus at six weeks post-stroke using Western blotting and immunohistochemical approaches. Western blotting analysis indicated that stroke was associated with a significant enhancement of the 25 and 50 kDa oligomers within the ipsilateral hemisphere and the 20 kDa oligomer within the contralateral hemisphere. Stroked animals exposed to stress exhibited an additional increase in multiple forms of Amyloid-beta oligomers. Immunohistochemistry analysis confirmed that stroke was associated with a significant accumulation of Amyloid-beta within the thalami of both hemispheres, an effect that was exacerbated in stroke animals exposed to stress. Given that Amyloid-beta oligomers, most notably the 30-40 and 50 kDa oligomers, are recognised to correlate with accelerated cognitive decline, our results suggest that monitoring stress levels in patients recovering from stroke may merit consideration in the future.
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2017 |
Krabbe D, Ellbin S, Nilsson M, Jonsdottir IH, Samuelsson H, 'Executive function and attention in patients with stress-related exhaustion: perceived fatigue and effect of distraction', Stress, 20 333-340 (2017) [C1] Cognitive impairment has frequently been shown in patients who seek medical care for stress-related mental health problems. This study aims to extend the current knowledge of cogn... [more] Cognitive impairment has frequently been shown in patients who seek medical care for stress-related mental health problems. This study aims to extend the current knowledge of cognitive impairments in these patients by focusing on perceived fatigue and effects of distraction during cognitive testing. Executive function and attention were tested in a group of patients with stress-related exhaustion (n = 25) and compared with healthy controls (n = 25). Perceived fatigue was measured before, during and after the test session, and some of the tests were administered with and without standardized auditory distraction. Executive function and complex attention performance were poorer among the patients compared to controls. Interestingly, their performance was not significantly affected by auditory distraction but, in contrast to the controls, they reported a clear-cut increase in mental tiredness, during and after the test session. Thus, patients with stress-related exhaustion manage to perform during distraction but this was achieved at a great cost. These findings are discussed in terms of a possible tendency to adopt a high-effort approach despite cognitive impairments and the likelihood that such an approach will require increased levels of effort, which can result in increased fatigue. We tentatively conclude that increased fatigue during cognitive tasks is a challenge for patients with stress-related exhaustion and plausibly of major importance when returning to work demanding high cognitive performance.
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2017 |
Ong LK, Zhao Z, Kluge M, TeBay C, Zalewska K, Dickson PW, et al., 'Reconsidering the role of glial cells in chronic stress-induced dopaminergic neurons loss within the substantia nigra? Friend or foe?', Brain, Behavior, and Immunity, 60 117-125 (2017) [C1] Exposure to psychological stress is known to seriously disrupt the operation of the substantia nigra (SN) and may in fact initiate the loss of dopaminergic neurons within the SN. ... [more] Exposure to psychological stress is known to seriously disrupt the operation of the substantia nigra (SN) and may in fact initiate the loss of dopaminergic neurons within the SN. In this study, we aimed to investigate how chronic stress modified the SN in adult male mice. Using a paradigm of repeated restraint stress (an average of 20¿h per week for 6¿weeks), we examined changes within the SN using western blotting and immunohistochemistry. We demonstrated that chronic stress was associated with a clear loss of dopaminergic neurons within the SN. The loss of dopaminergic neurons was accompanied by higher levels of oxidative stress damage, indexed by levels of protein carbonylation and strong suppression of both microglial and astrocytic responses. In addition, we demonstrated for the first time, that chronic stress alone enhanced the aggregation of a-synuclein into the insoluble protein fraction. These results indicate that chronic stress triggered loss of dopaminergic neurons by increasing oxidative stress, suppressing glial neuroprotective functions and enhancing the aggregation of the neurotoxic protein, a-synuclein. Collectively, these results reinforce the negative effects of chronic stress on the viability of dopaminergic cells within the SN.
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2017 |
Bhaskar S, Stanwell P, Bivard A, Spratt N, Walker R, Kitsos GH, et al., 'The influence of initial stroke severity on the likelihood of unfavourable clinical outcome and death at 90 days following acute ischemic stroke: A tertiary hospital stroke register study', Neurology India, 65 1252-1259 (2017) [C1]
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2017 |
Zhao Z, Ong LK, Johnson S, Nilsson M, Walker FR, 'Chronic stress induced disruption of the peri-infarct neurovascular unit following experimentally induced photothrombotic stroke.', Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 37 3709-3724 (2017) [C1]
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2017 |
Bhaskar S, Bivard A, Parsons M, Nilsson M, Attia JR, Stanwell P, Levi C, 'Delay of late-venous phase cortical vein filling in acute ischemic stroke patients: Associations with collateral status', Journal of Cerebral Blood Flow and Metabolism, 37 671-682 (2017) [C1]
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2017 |
Bhaskar S, Bivard A, Stanwell P, Parsons M, Attia JR, Nilsson M, Levi C, 'Baseline collateral status and infarct topography in post-ischaemic perilesional hyperperfusion: An arterial spin labelling study', Journal of Cerebral Blood Flow and Metabolism, 37 1148-1162 (2017) [C1] Focal hyperperfusion after acute ischaemic stroke could be of prognostic value depending upon its spatial localisation and temporal dynamics. Factors associated with late stage (1... [more] Focal hyperperfusion after acute ischaemic stroke could be of prognostic value depending upon its spatial localisation and temporal dynamics. Factors associated with late stage (12-24 h) perilesional hyperperfusion, identified using arterial spin labelling, are poorly defined. A prospective cohort of acute ischaemic stroke patients presenting within 4.5 h of symptom onset were assessed with multi-modal computed tomography acutely and magnetic resonance imaging at 24 ± 8 h. Multivariate logistic regression analysis and receiver operating characteristics curves were used. One hundred and nineteen hemispheric acute ischaemic stroke patients (mean age = 71 ± 12 years) with 24 h arterial spin labelling imaging were included. Forty-Two (35.3%) patients showed perilesional hyperperfusion on arterial spin labelling at 24 h. Several factors were independently associated with perilesional hyperperfusion: good collaterals (71% versus 29%, P < 0.0001; OR = 5, 95% CI = [1.6, 15.7], P = 0.005), major reperfusion (81% versus 48%, P = < 0.0001; OR = 7.5, 95% CI = [1.6, 35.1], P = 0.01), penumbral salvage (76.2% versus 47%, P = 0.002; OR = 6.6, 95% CI = [1.8, 24.5], P = 0.004), infarction in striatocapsular (OR = 9.5, 95% CI = [2.6, 34], P = 0.001) and in cortical superior division middle cerebral artery (OR = 4.7, 95% CI = [1.4, 15.7], P = 0.012) territory. The area under the receiver operating characteristic curve was 0.91. Our results demonstrate good arterial collaterals, major reperfusion, penumbral salvage, and infarct topographies involving cortical superior middle cerebral artery and striatocapsular are associated with perilesional hyperperfusion.
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2017 |
Turley JA, Zalewska K, Nilsson M, Walker FR, Johnson SJ, 'An analysis of signal processing algorithm performance for cortical intrinsic optical signal imaging and strategies for algorithm selection', SCIENTIFIC REPORTS, 7 (2017) [C1]
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2017 |
Zalewska K, Ong LK, Johnson SJ, Nilsson M, Walker FR, 'Oral administration of corticosterone at stress-like levels drives microglial but not vascular disturbances post-stroke', Neuroscience, 352 30-38 (2017) [C1] Exposure to chronic stress following stroke has been shown, both clinically and pre-clinically, to impact negatively on the recovery process. While this phenomenon is well establi... [more] Exposure to chronic stress following stroke has been shown, both clinically and pre-clinically, to impact negatively on the recovery process. While this phenomenon is well established, the specific mechanisms involved have remained largely unexplored. One obvious signaling pathway through which chronic stress may impact on the recovery process is via corticosterone, and its effects on microglial activity and vascular remodeling. In the current study, we were interested in examining how orally delivered corticosterone at a stress-like concentration impacted on microglial activity and vascular remodeling after stroke. We identified that corticosterone administration for two weeks following stroke significantly increased tissue loss and decreased the weight of the spleen and thymus. We also identified that corticosterone administration significantly altered the expression of the key microglial complement receptor, CD11b after stroke. Corticosterone administration did not alter the expression of the vessel basement membrane protein, Collagen IV after stroke. Together, these results suggest that corticosterone is likely to represent only one of the major stress signals responsible for driving the negative impacts of chronic stress on recovery.
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2017 |
Kluge MG, Kracht L, Abdolhoseini M, Ong LK, Johnson SJ, Nilsson M, Walker FR, 'Impaired microglia process dynamics post-stroke are specific to sites of secondary neurodegeneration', GLIA, 65 1885-1899 (2017) [C1] Stroke induces tissue death both at the site of infarction and at secondary sites connected to the primary infarction. This latter process has been referred to as secondary neurod... [more] Stroke induces tissue death both at the site of infarction and at secondary sites connected to the primary infarction. This latter process has been referred to as secondary neurodegeneration (SND). Using predominantly fixed tissue analyses, microglia have been implicated in regulating the initial response at both damage sites post-stroke. In this study, we used acute slice based multiphoton imaging, to investigate microglia dynamic process movement in mice 14 days after a photothrombotic stroke. We evaluated the baseline motility and process responses to locally induced laser damage in both the peri-infarct (PI) territory and the ipsilateral thalamus, a major site of post-stroke SND. Our findings show that microglia process extension toward laser damage within the thalamus is lost, yet remains robustly intact within the PI territory. However, microglia at both sites displayed an activated morphology and elevated levels of commonly used activation markers (CD68, CD11b), indicating that the standardly used fixed tissue metrics of microglial ¿activity¿ are not necessarily predictive of microglia function. Analysis of the purinergic P2Y12 receptor, a key regulator of microglia process extension, revealed an increased somal localization on nonresponsive microglia in the thalamus. To our knowledge, this is the first study to identify a non-responsive microglia phenotype specific to areas of SND post-stroke, which cannot be identified by the classical assessment of microglia activation but rather the localization of P2Y12 to the soma.
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2017 |
Deeming S, Searles A, Reeves P, Nilsson M, 'Measuring research impact in Australia's medical research institutes: a scoping literature review of the objectives for and an assessment of the capabilities of research impact assessment frameworks', HEALTH RESEARCH POLICY AND SYSTEMS, 15 (2017) [C1]
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2016 |
Bhaskar S, Bivard A, Stanwell P, Attia JR, Parsons M, Nilsson M, Levi C, 'Association of Cortical Vein Filling with Clot Location and Clinical Outcomes in Acute Ischaemic Stroke Patients', SCIENTIFIC REPORTS, 6 (2016) [C1]
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2016 |
Åberg MAI, Torén K, Nilsson M, Henriksson M, Kuhn HG, Nyberg J, et al., 'Nonpsychotic Mental Disorders in Teenage Males and Risk of Early Stroke: A Population-Based Study.', Stroke, 47 814-821 (2016) [C1]
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2016 |
Searles A, Doran C, Attia J, Knight D, Wiggers J, Deeming S, et al., 'An approach to measuring and encouraging research translation and research impact', HEALTH RESEARCH POLICY AND SYSTEMS, 14 (2016) [C1]
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2016 |
Lubans D, Richards J, Hillman C, Faulkner G, Beauchamp M, Nilsson M, et al., 'Physical Activity for Cognitive and Mental Health in Youth: A Systematic Review of Mechanisms', PEDIATRICS, 138 (2016) [C1]
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2015 |
Bidarian-Moniri A, Nilsson M, Rasmusson L, Attia J, Ejnell H, 'The effect of the prone sleeping position on obstructive sleep apnoea', ACTA OTO-LARYNGOLOGICA, 135 79-84 (2015) [C1]
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2015 |
Levy SC, Freed DJ, Nilsson M, Moore BCJ, Puria S, 'Extended High-Frequency Bandwidth Improves Speech Reception in the Presence of Spatially Separated Masking Speech', EAR AND HEARING, 36 E214-E224 (2015)
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2015 |
Bidarian-Moniri A, Nilsson M, Attia J, Ejnell H, 'Mattress and pillow for prone positioning for treatment of obstructive sleep apnoea', Acta Oto-Laryngologica, 135 271-276 (2015) [C1] Conclusion: The new mattress and pillow for prone positioning (MPP) is efficient in reducing the apnoea-hypopnoea index (AHI) and oxygen desaturation index (ODI) in most patients ... [more] Conclusion: The new mattress and pillow for prone positioning (MPP) is efficient in reducing the apnoea-hypopnoea index (AHI) and oxygen desaturation index (ODI) in most patients with obstructive sleep apnoea (OSA), with satisfactory compliance. Objective: The aim of the present study was to evaluate the effect of the prone body and head sleep position on severity of disease in patients with OSA after 4 weeks of adaptation to a mattress and pillow facilitating prone positioning. Methods: Fourteen patients with mild to severe OSA, 11 men and 3 women with a mean AHI of 26 (min, 6; max, 53) and mean ODI of 21 (min, 6; max, 51) were evaluated. Two polysomnographic (PSG) studies were performed. The first PSG study was without any treatment and the second was after 4 weeks of adaptation to the MPP for prone positioning of the body and the head. Results: Mean AHI and ODI decreased from 26 and 21 to 8 and 7, respectively (p < 0.001) with treatment. The mean time spent in the supine position was reduced from 128 to 10 min (p = 0.02) and the prone time increased from 42 to 174 min (p = 0.02) with the MPP. The mean total sleep time was 390 min during the first PSG study night without treatment and 370 min during the second night with the MPP (p = 0.7). Ten patients (71%) reduced their AHI by at least 50% and reached a value < 10 during treatment. All patients managed to sleep on the MPP for > 4 h per night during the 4-week study.
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2015 |
Kongsui R, Johnson SJ, Graham BA, Nilsson M, Walker FR, 'A combined cumulative threshold spectra and digital reconstruction analysis reveal structural alterations of microglia within the prefrontal cortex following low-dose LPS administration', Neuroscience, 310 629-640 (2015) [C1] Sickness behaviors have become the focus of great interest in recent years as they represent a clear case of how peripheral disturbances in immune signaling can disrupt quite comp... [more] Sickness behaviors have become the focus of great interest in recent years as they represent a clear case of how peripheral disturbances in immune signaling can disrupt quite complex behaviors. In the current study, we were interested in examining whether we could identify any significant morphological disturbances in microglia associated with these sickness-like behaviors in adult male Sprague-Dawley rats. We chose lipopolysaccharide (LPS 100 µg/kg/i.p.), to induce sickness-like behaviors as it is the most well-validated approach to do so in rodents and humans. We were particularly interested in examining changes in microglia within the prefrontal cortex (PFC) as several recent neuroimaging studies have highlighted significant functional changes in this region following peripheral LPS administration. Paraformaldehyde-fixed tissue was collected from animals 24 h post LPS administration and labeled immunohistochemically with an antibody directed to bind to Iba-1, a protein known to be involved in the structural remodeling of microglia. To analyze changes, we have made use of two recently described image analysis procedures. The first is known as cumulative threshold spectra (CTS) analysis. The second involves the unsupervised digital reconstruction of microglia. We undertook these complementary analysis of microglial cells in the both the pre- and infralimbic divisions of the PFC. Our results indicated that microglial soma size was significantly enlarged, while cell processes had contracted slightly following LPS administration. To our knowledge this study is to first to definitely demonstrate substantial microglial disturbances within the PFC following LPS delivered at a dose that was sufficient to induce significant sickness-like behavior.
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2015 |
Patience MJ, Zouikr I, Jones K, Clarkson AN, Isgaard J, Johnson SJ, et al., 'Photothrombotic Stroke Induces Persistent Ipsilateral and Contralateral Astrogliosis in Key Cognitive Control Nuclei', NEUROCHEMICAL RESEARCH, 40 362-371 (2015) [C1]
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2015 |
Jones KA, Zouikr I, Patience M, Clarkson AN, Isgaard J, Johnson SJ, et al., 'Chronic stress exacerbates neuronal loss associated with secondary neurodegeneration and suppresses microglial-like cells following focal motor cortex ischemia in the mouse', Brain, Behavior, and Immunity, 48 57-67 (2015) [C1]
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2015 |
Käll LB, Lindén T, Nilsson M, 'Käll, Lindén, and Nilsson Respond: The Impact of a Physical Activity Intervention Program on Academic Achievement', Journal of School Health, 85 279-280 (2015) [C3]
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2015 |
Clarkson AN, Parker K, Nilsson M, Walker FR, Gowing EK, 'Combined ampakine and BDNF treatments enhance poststroke functional recovery in aged mice via AKT-CREB signaling.', J Cereb Blood Flow Metab, 35 1272-1279 (2015) [C1]
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2015 |
Bunketorp Käll L, Malmgren H, Olsson E, Lindén T, Nilsson M, 'Effects of a Curricular Physical Activity Intervention on Children's School Performance, Wellness, and Brain Development', Journal of School Health, 85 704-713 (2015) [C1] BACKGROUND: Physical activity and structural differences in the hippocampus have been linked to educational outcome. We investigated whether a curriculum-based physical activity i... [more] BACKGROUND: Physical activity and structural differences in the hippocampus have been linked to educational outcome. We investigated whether a curriculum-based physical activity intervention correlates positively with children's academic achievement, psychological well-being, health-related quality of life (HRQoL), fitness, and structural development of the brain. METHODS: The study had a quasi-experimental design and a control group. National test results were gathered from 545 students, 122 in the intervention school, and 423 in 3 control schools. HRQoL and socioemotional data were collected with child and proxy versions of KIDSCREEN and the Strength and Difficulties Questionnaire. Overall, 79 students in grades 5 and 6 were recruited for an in-depth study, consisting of a submaximal oxygen consumption test and magnetic resonance imaging of the brain. HRQoL and socioemotional data were collected from 349 students (65%), 182 (52%) in the intervention school, and 167 (48%) in one of the control schools. RESULTS: Girls attending the intervention school were more likely to pass national tests in Swedish (odds ratio 5.7) and Mathematics (odds ratio 3.2). The fourth to sixth graders in the intervention school reported lower levels of conduct problems (p<.05), and the girls were also less likely to report hyperactivity (p<.05). Girls reported higher levels of emotional problems (p<.05) than boys. Boys in the intervention group had significantly higher levels of estimated maximal oxygen uptake (p<.05) than controls. No difference in hippocampal structure was seen. CONCLUSIONS: Curriculum-based physical activity in school may improve the academic achievement and psychological health of children, particularly for girls.
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2015 |
Aberg ND, Kuhn HG, Nyberg J, Waern M, Friberg P, Svensson J, et al., 'Influence of Cardiovascular Fitness and Muscle Strength in Early Adulthood on Long-Term Risk of Stroke in Swedish Men', STROKE, 46 1769-1776 (2015) [C1]
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2014 |
Malmevik J, Rogers ML, Nilsson M, Nakanishi Y, Rush RA, Sims NR, Muyderman H, 'Selective transfection of microglia in the brain using an antibody-based non-viral vector', Brain Research, 1586 12-22 (2014) [C1] There are currently few approaches to transiently manipulate the expression of specific proteins in microglia of the brain. An antibody directed against an extracellular epitope o... [more] There are currently few approaches to transiently manipulate the expression of specific proteins in microglia of the brain. An antibody directed against an extracellular epitope of scavenger receptor class B, type I (SR-BI) was found to be selectively taken up by these cells in the brain. Other antibodies tested were not internalised by microglia. A vector was produced by linking the SR-BI antibody to polyethyleneimine and binding a DNA plasmid encoding green fluorescent protein. Infusions of this vector into the hippocampus produced a widespread transfection of cells, more than 80% of which were immunoreactive for microglial/macrophage markers. Transfection was not detected in cells expressing markers for astrocytes or neurons. Reporter gene expression was most prominent near the infusion site but was seen in tissue up to 4 mm away. DNA bound to polyethyleneimine alone or to a vector containing a different antibody did not produce transfection in the brain. Single injections of the vector containing the SR-BI antibody into the brain also resulted in transfection of microglia, albeit with lower efficiency. Vector modifications to promote lysis of endosomes or entry of DNA into the nucleus did not increase efficiency. The findings clearly demonstrate the capacity of the SR-BI antibody to selectively target brain microglia. This approach offers considerable potential to deliver DNA and other molecules capable of modifying the function of these cells in vivo.
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2014 |
Nyberg J, Aberg MAI, Schiöler L, Nilsson M, Wallin A, Torén K, Kuhn HG, 'Cardiovascular and cognitive fitness at age 18 and risk of early-onset dementia', Brain, 137 1514-1523 (2014) [C1] Patients with early-onset dementia are a significantly under-recognized subgroup of patients with an increasing prevalence. Epidemiological studies are limited and studies of modi... [more] Patients with early-onset dementia are a significantly under-recognized subgroup of patients with an increasing prevalence. Epidemiological studies are limited and studies of modifiable risk factors, such as physical fitness, are lacking. We aimed to investigate the associations between cardiovascular fitness individually and in combination with cognitive performance at age 18 and risk of early-onset dementia and mild cognitive impairment later in life. We performed a population-based cohort study of over 1.1 million Swedish, 18-year-old, male conscripts, who underwent conscription exams between 1968 and 2005. These males were then followed for up to 42 years. Objective data on cardiovascular fitness and cognitive performance were collected during conscription exams and were subsequently linked with hospital registries to calculate later risk of early-onset dementia and mild cognitive impairment using Cox proportional hazards models controlling for several confounders. The scores from the exams were divided into tertiles (low, medium, high) for the analyses. The mean follow-up time for the analyses was 25.7 years (standard deviation: 9.3) and the median was 27 years. In total, 30 195 315 person-years of follow-up were included in the study. In fully adjusted models, both low cardiovascular fitness and cognitive performance (compared to high) at age 18 were associated with increased risk for future early-onset dementia (cardiovascular fitness, n = 662 events: hazard ratio 2.49, 95%, confidence interval 1.87-3.32; cognitive performance, n = 657 events: hazard ratio 4.11, 95%, confidence interval 3.19-5.29) and mild cognitive impairment (cardiovascular fitness, n = 213 events: hazard ratio 3.57, 95%, confidence interval 2.23-5.74; cognitive performance, n = 212 events: hazard ratio 3.23, 95%, confidence interval 2.12-4.95). Poor performance on both cardiovascular fitness and cognitive tests was associated with a >7-fold (hazard ratio 7.34, 95%, confidence interval 5.08-10.58) and a >8-fold (hazard ratio 8.44, 95%, confidence interval 4.64-15.37) increased risk of early-onset dementia and early-onset mild cognitive impairment, respectively. In conclusion, lower cardiovascular fitness and cognitive performance in early adulthood were associated with an increased risk of early-onset dementia and mild cognitive impairment later in life, and the greatest risks were observed for individuals with a combination of low cardiovascular fitness and low cognitive performance. © 2014 The Author (2014). Published by Oxford University Press on behalf of the Guarantors of Brain. All rights reserved.
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2014 |
Käll LB, Nilsson M, Lindén T, 'The impact of a physical activity intervention program on academic achievement in a swedish elementary school setting', Journal of School Health, 84 473-480 (2014) [C1] BACKGROUND: Despite the emerging body of research on the potential of physical activity to improve learning and academic achievement, conclusive evidence regarding the effects of ... [more] BACKGROUND: Despite the emerging body of research on the potential of physical activity to improve learning and academic achievement, conclusive evidence regarding the effects of physical activity on academic achievement is lacking. The objective of this study was to determine the impact of a physical activity intervention program on academic performance. METHODS: A controlled cross-sectional design was used to investigate the hypothesis that the intervention program would increase the proportion of students in grade 5 who achieved the national learning goals in Swedish, mathematics, and English compared with 3 reference schools. Academic results from the years prior to and during the intervention program were analyzed. Logistic regression analyses assessed the odds of achieving the national learning goals when the intervention program was integrated into the elementary curricula. RESULTS: Higher proportions of students in the intervention school achieved the national goals in all 3 subjects compared with the reference schools after initiation of the intervention program. The odds for achieving the national learning goals in the intervention school increased 2-fold (p<.05), whereas these odds either did not change or decreased in the reference schools. CONCLUSION: Promoting physical activity in school by means of a curriculum-based intervention program may improve children's educational outcome. © 2014, American School Health Association.
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2014 |
Sjöholm A, Skarin M, Churilov L, Nilsson M, Bernhardt J, Lindén T, 'Sedentary behaviour and physical activity of people with stroke in rehabilitation hospitals.', Stroke Res Treat, 2014 591897 (2014) [C1]
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2014 |
Janssen H, Ada L, Bernhardt J, McElduff P, Pollack M, Nilsson M, Spratt N, 'Physical, cognitive and social activity levels of stroke patients undergoing rehabilitation within a mixed rehabilitation unit', Clinical Rehabilitation, 28 91-101 (2014) [C1] Objective: To determine physical, cognitive and social activity levels of stroke patients undergoing rehabilitation, and whether these changed over time. Design: Observational stu... [more] Objective: To determine physical, cognitive and social activity levels of stroke patients undergoing rehabilitation, and whether these changed over time. Design: Observational study using behavioural mapping techniques to record patient activity over 12 hours on one weekday and one weekend day at baseline (week 1) and again two weeks later (week 2). Setting: A 20-bed mixed rehabilitation unit. Subjects: Fourteen stroke patients. Interventions: None. Main measures: Percentage of day spent in any activity or physical, cognitive and social activities. Level of independence using the Functional Independence Measure (FIM) and mood using the Patient Health Questionniare-9 (PHQ-9). Results: The stroke patients performed any activity for 49%, social activity for 32%, physical activity for 23% and cognitive activity for 4% of the day. Two weeks later, physical activity levels had increased by 4% (95% confidence interval (CI) 1 to 8), but levels of any activity or social and cognitive activities had not changed significantly. There was a significant: (i) positive correlation between change in physical activity and change in FIM score (r = 0.80), and (ii) negative correlation between change in social activity and change in PHQ-9 score (r = -0.72). The majority of activity was performed by the bedside (37%), and most physical (47%) and cognitive (54%) activities performed when alone. Patients undertook 5% (95% CI 2 to 9) less physical activity on the weekends compared with the weekdays. Conclusions: Levels of physical, cognitive and social activity of stroke patients were low and remained so even though level of independence and mood improved. These findings suggest the need to explore strategies to stimulate activity within rehabilitation environments. © The Author(s) 2013.
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2014 |
Ulfarsson T, Lundgren-Nilsson A, Blomstrand C, Nilsson M, 'A history of unemployment or sick leave influences long-term functioning and health-related quality-of-life after severe traumatic brain injury', BRAIN INJURY, 28 328-335 (2014) [C1]
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2014 |
Walker FR, Jones KA, Patience MJ, Zhao Z, Nilsson M, 'Stress as necessary component of realistic recovery in animal models of experimental stroke', JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 34 208-214 (2014) [C1]
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2014 |
Bivard A, Krishnamurthy V, Stanwell P, Yassi N, Spratt NJ, Nilsson M, et al., 'Spectroscopy of reperfused tissue after stroke reveals heightened metabolism in patients with good clinical outcomes', JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 34 1944-1950 (2014) [C1]
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2014 |
Walker FR, Beynon SB, Jones KA, Zhao Z, Kongsui R, Cairns M, Nilsson M, 'Dynamic structural remodelling of microglia in health and disease: A review of the models, the signals and the mechanisms', BRAIN BEHAVIOR AND IMMUNITY, 37 1-14 (2014) [C1]
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2014 |
Kongsui R, Beynon SB, Johnson SJ, Mayhew J, Kuter P, Nilsson M, Walker FR, 'Chronic stress induces prolonged suppression of the P2X7 receptor within multiple regions of the hippocampus: A cumulative threshold spectra analysis', Brain, Behavior, and Immunity, 42 69-80 (2014) [C1]
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2014 |
Janssen H, Ada L, Bernhardt J, McElduff P, Pollack M, Nilsson M, Spratt NJ, 'An enriched environment increases activity in stroke patients undergoing rehabilitation in a mixed rehabilitation unit: a pilot non-randomized controlled trial', DISABILITY AND REHABILITATION, 36 255-262 (2014) [C1]
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2014 | Nilsson M, Johansson E, Liang S, Fagman H, 'Divergent roles of forkhead family transcription factor paralogs in medullary thyroid carcinoma', WIENER KLINISCHE WOCHENSCHRIFT, 126 S157-S158 (2014) [E3] | ||||||||||
2014 |
Ulfarsson T, Lundgren-Nilsson A, Blomstrand C, Jakobsson K-E, Oden A, Nilsson M, Rosen T, 'Ten-year mortality after severe traumatic brain injury in western Sweden: A case control study', BRAIN INJURY, 28 1675-1681 (2014) [C1]
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2014 |
von Otter M, Bergstrm P, Quattrone A, De Marco EV, Annesi G, Sderkvist P, et al., 'Genetic associations of Nrf2-encoding
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2014 |
Tjärnlund-Wolf A, Hultman K, Blomstrand F, Nilsson M, Medcalf RL, Jern C, 'Species-specific regulation of t-PA and PAI-1 gene expression in human and rat astrocytes', Gene Regulation and Systems Biology, 2014 113-118 (2014) [C1] In recent years, the role and physiological regulation of the serine protease tissue-type plasminogen activator (t-PA and its inhibitors, including plasminogen activator inhibitor... [more] In recent years, the role and physiological regulation of the serine protease tissue-type plasminogen activator (t-PA and its inhibitors, including plasminogen activator inhibitor type-1 (PAI-1, in the brain have received much attention. However, as studies focusing these issues are difficult to perform in humans, a great majority of the studies conducted to date have utilized rodent in vivo and/or in vitro models. In view of the species-specific structural differences present in both the t-PA and the PAI-1 promoters, we have compared the response of these genes in astrocytes of rat and human origin. We reveal marked quantitative and qualitative species-specific differences in gene induction following treatment with various physiological and pathological stimuli. Thus, our findings are of importance for the interpretation of previous and future results related to t-PA and PAI-1 expression. © the authors, publisher and licensee Libertas Academica Limited.
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2013 |
Vickhoff B, Malmgren H, Åström R, Nyberg GF, Ekström SR, Engwall M, et al., 'Erratum: Music structure determines heart rate variability of singers', Frontiers in Psychology, 4 (2013) [C3]
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2013 |
Khoff B, Malmgren H, Åström R, Nyberg G, Ekström S-R, Engwall M, et al., 'Music structure determines heart rate variability of singers', Frontiers in Psychology, 4 (2013) [C1]
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2013 |
Fay JP, Perkins R, Levy SC, Nilsson M, Puria S, 'Preliminary Evaluation of a Light-Based Contact Hearing Device for the Hearing Impaired', OTOLOGY & NEUROTOLOGY, 34 912-921 (2013)
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2013 |
Tynan RJ, Beynon SB, Hinwood M, Johnson SJ, Nilsson M, Woods JJ, Walker FR, 'Chronic stress-induced disruption of the astrocyte network is driven by structural atrophy and not loss of astrocytes', Acta Neuropathologica, 126 75-91 (2013) [C1]
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2013 |
Nyberg J, Åberg MAI, Torén K, Nilsson M, Ben-Menachem E, Georg Kuhn H, 'Cardiovascular fitness and later risk of epilepsy: A Swedish population-based cohort study', Neurology, 81 1051-1057 (2013) [C1] Objective: To analyze the associations between cardiovascular fitness at age 18 years and future risk of epilepsy. Methods: Population-based cohort study of Swedish male conscript... [more] Objective: To analyze the associations between cardiovascular fitness at age 18 years and future risk of epilepsy. Methods: Population-based cohort study of Swedish male conscripts (n = 1,173,079) born in 1950-1987, who were followed for up to 40 years. Data on cardiovascular fitness were collected during conscription exams and linked with hospital registers to calculate later risk of epilepsy using Cox proportional hazard models controlling for several confounders, including familial factors. Results: Epilepsy was recorded in 6,796 individuals during the follow-up time. In fully adjusted models, low and medium cardiovascular fitness (compared with high) at age 18 years was associated with increased risk of future epilepsy (hazard ratio 1.79, 95% confidence interval 1.57-2.03; and hazard ratio 1.36, 95% confidence interval 1.27-1.45, respectively). The associations changed only marginally after adjustment for familial influences and prior severe traumatic brain injury, cerebrovascular disease, or diabetes. Conclusions: Low cardiovascular fitness early in life is associated with an increased risk of epilepsy later in adulthood. These results agree with previous results from animal models. We propose that behaviors that increase cardiovascular fitness may act as positive disease-modifiers for the development of epilepsy. © 2013 American Academy of Neurology.
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2013 |
Kuhn HG, Åberg MAI, Waern M, Nyberg J, Nilsson M, Pedersen NL, et al., 'Authors' reply', British Journal of Psychiatry, 202 311 (2013)
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2013 |
Nilsson M, Hägglund M, Ekstrand J, Waldén M, 'Head and neck injuries in professional soccer', Clinical Journal of Sport Medicine, 23 255-260 (2013) OBJECTIVE: To investigate the rate of and risk factors for head and neck injury in male soccer. DESIGN: Prospective cohort study. SETTING: Professional soccer. PARTICIPANTS: Twent... [more] OBJECTIVE: To investigate the rate of and risk factors for head and neck injury in male soccer. DESIGN: Prospective cohort study. SETTING: Professional soccer. PARTICIPANTS: Twenty-six European teams between 2001/2002 and 2009/2010. ASSESSMENT OF RISK FACTORS: Simple and multiple risk factor analyses were evaluated using Cox regression for player-related variables and logistic regression for match-related variables. MAIN OUTCOME MEASURES: Injury rate (number of time loss injuries per 1000 hours). RESULTS: A total of 136 head and neck injuries were recorded (2.2% of all injuries). The head and neck injury rate was 0.17 (0.06 concussions) per 1000 hours. There was a 20-fold higher rate of head and neck injury during match play compared with training (rate ratio [RR], 20.2; 95% confidence interval [CI], 13.3-30.6) and a 78-fold higher rate of concussions (RR, 78.5; 95% CI, 24.4-252.5). Mean layoff for concussion was 10.5 days, but 27% of the concussed players returned to play within 5 days. Defender was the only significant player-related risk factor for head and neck injuries in the multiple analysis (RR, 1.8; 95% CI, 1.0-3.1), whereas no significant variables were identified for concussions. CONCLUSIONS: Head and neck injuries were relatively uncommon in professional soccer. Defender was the playing position most at risk. More than one-quarter of the concussed players returned to play before what is recommended in the consensus statements by the major sports governing bodies. Copyright © 2013 by Lippincott Williams & Wilkins.
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2013 |
Aberg ND, Olsson S, Aberg D, Jood K, Stanne TM, Nilsson M, et al., 'Genetic variation at the
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2013 |
Ulfarsson T, Arnar Gudnason G, Rosén T, Blomstrand C, Stibrant Sunnerhagen K, Lundgren-Nilsson A, Nilsson M, 'Pituitary function and functional outcome in adults after severe traumatic brain injury: The long-term perspective', Journal of Neurotrauma, 30 271-280 (2013) [C1] Post-traumatic hypopituitarism (PTHP) has been linked to disability and decreased quality of life. However, no studies have addressed the long-term consequences of PTHP in adults ... [more] Post-traumatic hypopituitarism (PTHP) has been linked to disability and decreased quality of life. However, no studies have addressed the long-term consequences of PTHP in adults with severe traumatic brain injury (TBI) only. In this study, we evaluated the relationship between pituitary function, quality of life, and functioning in 51 patients (16-65 years of age) with severe TBI who were admitted to Sahlgrenska University Hospital, Gothenburg from 1999 to 2002. The patients were assessed once, 2-10 years after trauma. Data from the time of injury were collected retrospectively to adjust for injury severity. Outcome measures included hormonal testing, the Short Form-36 Health Survey, the Glasgow Outcome Scale-Extended, and a self-report questionnaire specifically designed for this study and based on the International Classification of Functioning, Disability and Health. Of 51 patients, 14 (27.5%) presented with PTHP, and 11 (21.6%) had isolated growth hormone deficiency. Patients with PTHP were more often overweight at follow-up (p=0.01); the higher body mass index was partially explained by PTHP (R2 change=0.07, p=0.001). Otherwise no significant correlation was found among PTHP, functioning, or patient-reported quality of life. This study - which is unique in the homogeneity of the patients, the long follow-up time, and the use of injury severity as an outcome predictor - did not confirm results from previous studies linking PTHP to a worse outcome. Therefore, screening for PTHP might be restricted to specific subgroups such as overweight patients, indicating growth hormone deficiency. © 2013, Mary Ann Liebert, Inc.
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2013 |
de Pablo Y, Nilsson M, Pekna M, Pekny M, 'Intermediate filaments are important for astrocyte response to oxidative stress induced by oxygen-glucose deprivation and reperfusion', HISTOCHEMISTRY AND CELL BIOLOGY, 140 81-91 (2013) [C1]
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2013 |
Walker FR, Nilsson M, Jones K, 'Acute and Chronic Stress-Induced Disturbances of Microglial Plasticity, Phenotype and Function', Current Drug Targets, 14 1262-1276 (2013) [C1]
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2013 |
Skarin M, Sjoholm A, Nilsson AL, Nilsson M, Bernhardt J, Linden T, 'A MAPPING STUDY ON PHYSICAL ACTIVITY IN STROKE REHABILITATION: ESTABLISHING THE BASELINE', JOURNAL OF REHABILITATION MEDICINE, 45 997-1003 (2013) [C1]
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2013 |
Andersson D, Wilhelmsson U, Nilsson M, Kubista M, Stahlberg A, Pekna M, Pekny M, 'Plasticity Response in the Contralesional Hemisphere after Subtle Neurotrauma: Gene Expression Profiling after Partial Deafferentation of the Hippocampus', PLOS ONE, 8 (2013) [C1]
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2012 |
Bunketorp Kall L, Lundgren-Nilsson A, Blomstrand C, Pekna M, Pekny M, Nilsson M, 'The effects of a rhythm and music-based therapy program and therapeutic riding in late recovery phase following stroke: A study protocol for a three-armed randomized controlled trial', BMC Neurology, 12 141 (2012) [C3]
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2012 |
Janssen H, Ada L, Karayanidis F, Drysdale K, McElduff P, Pollack MR, et al., 'Translating the use of an enriched environment poststroke from bench to bedside: study design and protocol used to test the feasibility of environmental enrichment on stroke patients in rehabilitation', International Journal of Stroke, 7 521-526 (2012) [C3]
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2012 |
Van Vliet PM, Carey L, Nilsson M, 'Targeting stroke treatment to the individual', International Journal of Stroke, 7 480-481 (2012) [C3]
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2010 |
Janssen H, Bernhardt J, Collier JM, Sena ES, McElduff P, Attia JR, et al., 'An enriched environment improves sensorimotor function post-ischemic stroke', Neurorehabilitation and Neural Repair, 24 802-813 (2010) [C1]
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Show 230 more journal articles |
Conference (67 outputs)
Year | Citation | Altmetrics | Link | ||||||||
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2023 |
Janssen H, Sammut M, Pickering R, Preece J, Sweetapple A, Garcia-Esperon C, et al., 'Evaluation of the health service delivered secondary prevention program: Supporting Lifestyle and Activity Modification after TIA (SLAM-TIA)', INTERNATIONAL JOURNAL OF STROKE (2023)
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2023 |
Janssen H, Hasnain M, Owen S, Brown A, Smallwood R, Usher K, et al., 'Evidence for the use of co-design with Aboriginal and/or Torres Strait Islander People to strengthen cardiovascular health: A scoping review', INTERNATIONAL JOURNAL OF STROKE (2023)
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2023 |
Paul M, Paul J, Hinwood M, Martin K, Hood R, Johnson S, et al., 'Clopidogrel Administration Impairs Post-Stoke Learning and Memory Recovery in Mice', Newcastle (2023)
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2016 |
Walker F, Jones K, Zhao Z, Ong LK, Kluge M, Zalewska K, et al., 'Secondary neurodegeneration after stroke is exacerbated by stress: A new opportunity for preserving viable brain tissue', BRAIN BEHAVIOR AND IMMUNITY (2016)
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2015 | Searles AM, Nilsson M, Bernhardt J, Cadilhac D, Doran C, Webb B, Deeming S, 'Applying a framework to access the impact from transnational health-research (FAIT)', 4th Annual NHMRC Symposium on Research Translation jointly with CIPHER, Sydney, NSW (2015) [E3] | ||||||||||
2015 | Doran C, Searles A, Nilsson M, Webb B, Deeming S, 'HMRI framework to assess the impact from transnational research (FAIT)', 4th Annual NHMRC Symposium on Research Translation jointly with CIPHER, Sydney, NSW (2015) [E3] | ||||||||||
2015 |
Bhaskar S, Bivard A, Parsons M, Nilsson M, Attia J, Stanwell P, Levi C, 'Delay of late-venous phase cortical vein filling in acute ischemic stroke patients', Vienna, Austria (2015) [E3]
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2015 |
Walker FR, Jones K, Zouikr I, Patience M, Clarkson A, Isgaard J, et al., 'Understanding "Stress X Microglial interactions" in stroke-induced secondary neurodegeneration: a major opportunity for the preser', JOURNAL OF NEUROCHEMISTRY, Cairns, AUSTRALIA (2015) [E3]
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2015 |
Walker FR, Zouikr I, Patience M, Clarkson A, Isgaard J, Johnson S, et al., 'Chronic stress exacerbates neuronal loss associated with secondary neurodegeneration and suppresses microglial-like cells following focal motor cortex ischemia in the mouse', GLIA, Bilbao, SPAIN (2015) [E3]
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2015 |
Turley JA, Nilsson M, Walker FR, Johnson SJ, 'A comparison of signal processing techniques for Intrinsic Optical Signal imaging in mice', Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS (2015) [E1] Intrinsic Optical Signal imaging is a technique which allows the visualisation and mapping of activity related changes within the brain with excellent spatial and temporal resolut... [more] Intrinsic Optical Signal imaging is a technique which allows the visualisation and mapping of activity related changes within the brain with excellent spatial and temporal resolution. We analysed a variety of signal and image processing techniques applied to real mouse imaging data. The results were compared in an attempt to overcome the unique issues faced when performing the technique on mice and improve the understanding of post processing options available.
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2015 |
Smith H, Marquez J, Ada L, Spratt NJ, Nilsson M, Pollack M, et al., 'Quantifying physical, cognitive and social activity early after stroke: How enriched is the acute stroke environment?', INTERNATIONAL JOURNAL OF STROKE (2015) [E3]
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2014 | Deeming S, Nilsson M, Webb B, Searles A, Doran C, 'DEVELOPING THE HMRI FRAMEWORK FOR MEASURING RESEARCH IMPACT', ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY (2014) [E3] | ||||||||||
2014 |
Bidarian-Moniri A, Nilsson M, Attia J, Ejnell H, 'Prone positioning for treatment of obstructive sleep apnoea', JOURNAL OF SLEEP RESEARCH, Tallinn, ESTONIA (2014) [E3]
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2013 |
Tynan R, Beynon S, Nilsson M, Walker F, 'CHRONIC STRESS INDUCES PROFOUND STRUCTURAL REMODELLING OF ASTROCYTES WITHIN THEPREFRONTAL CORTEX: A CHARACTERIZATION OF THE RELATIONSHIP BETWEEN ASTROCYTE MORPHOLOGYAND DENSITY', GLIA, Berlin, GERMANY (2013) [E3]
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2012 |
Janssen H, Ada L, Bernhardt J, Karayanidis F, Drysdale K, McElduff P, et al., 'The use of an enriched environment post stroke: Translating from bench to bedside', Neurorehabilitation & Neural Repair: WCNR 2012 Oral Abstracts, Melbourne, VIC (2012) [E3]
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2012 | Nilsson M, 'New approaches to stroke recovery', Journal of Molecular Neuroscience: Abstracts The 21st Annual Meeting of the Israel Society for Neuroscience & The First Binational Australian-Israeli Meeting in Neuroscience, Eilat, Israel (2012) [E3] | ||||||||||
Show 64 more conferences |
Creative Work (1 outputs)
Year | Citation | Altmetrics | Link |
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1991 | Hansson E, Wagberg M, Eriksson P, Nilsson M, Ronnback L, Astrocytes - One key to brain function, Goteborgs, Sweden (1991) [J2] |
Preprint (5 outputs)
Year | Citation | Altmetrics | Link | |||||
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2023 |
Ribbons K, Johnson S, Ditton E, Wills A, Mason G, Flynn T, et al., 'Using Presurgical Biopsychosocial Features to Develop an Advanced Clinical Decision-Making Support Tool for Predicting Recovery Trajectories in Patients Undergoing Total Knee Arthroplasty: Protocol for a Prospective Observational Study (Preprint) (2023)
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2023 |
Ribbons K, Johnson S, Ditton E, Wills A, Mason G, Flynn T, et al., 'Using Presurgical Biopsychosocial Features to Develop an Advanced Clinical Decision-Making Support Tool for Predicting Recovery Trajectories in Patients Undergoing Total Knee Arthroplasty: Protocol for a Prospective Observational Study (2023)
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2022 |
Ditton E, Knott B, Hodyl N, Horton G, Walker FR, Nilsson M, 'Correction: Assessing the Efficacy of an Individualized Psychological Flexibility Skills Training Intervention App for Medical Student Burnout and Well-being: Protocol for a Randomized Controlled Trial (Preprint) (2022)
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Show 2 more preprints |
Thesis / Dissertation (1 outputs)
Year | Citation | Altmetrics | Link |
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1992 | Nilsson M, Astrocytes, neurotransmitters and valproate. A study with reference to uptake kinetics and receptor-evoked Ca-transients in astroglial primary culture, University of Gothenburg, Gothenburg, Sweden (1992) [T1] |
Grants and Funding
Summary
Number of grants | 41 |
---|---|
Total funding | $13,381,906 |
Click on a grant title below to expand the full details for that specific grant.
20241 grants / $631,475
EngAGE: A strategy for Improving Mental, Physical, and Social Wellbeing through Interactive Exercise, being the Project described in the Project Plan$631,475
Funding body: Hunter New England and Central Coast Primary Health Network (HNECC)
Funding body | Hunter New England and Central Coast Primary Health Network (HNECC) |
---|---|
Project Team | Professor Rohan Walker, Dr Nattai Borges, Professor Michael Nilsson, Doctor Mitch Smith, Dr Kemi Wright |
Scheme | Research Grant |
Role | Investigator |
Funding Start | 2024 |
Funding Finish | 2026 |
GNo | G2400136 |
Type Of Funding | C3200 – Aust Not-for Profit |
Category | 3200 |
UON | Y |
20234 grants / $2,158,968
ESTEEM After Stroke: Improving access to stroke rehabilitation for regional Australians$1,514,537
Funding body: Department of Health and Aged Care
Funding body | Department of Health and Aged Care |
---|---|
Project Team | Doctor Heidi Janssen, Dr Marie-Louise Bird, Professor Michael Nilsson, Doctor Liam Johnson, Dr Liam Johnson, Professor Neil Spratt, Professor Coralie English, Conjoint Professor Chris Levi, Doctor Carlos Garcia Esperon, Dr Christine Shiner, Doctor Kirsti Haracz, Doctor Dawn Simpson, Dr Christopher Oldmeadow, Doctor Christopher Oldmeadow |
Scheme | MRFF - CRI - Clinician Researchers: Nurses, Midwives and Allied Health |
Role | Investigator |
Funding Start | 2023 |
Funding Finish | 2026 |
GNo | G2200912 |
Type Of Funding | C1300 - Aust Competitive - Medical Research Future Fund |
Category | 1300 |
UON | Y |
The IMPACT Program – Innovations in the Management of Pain: Approaches to Care Transformed$444,664
Funding body: QBE Insurance (Australia) Ltd
Funding body | QBE Insurance (Australia) Ltd |
---|---|
Project Team | Professor Michael Nilsson, Conjoint Associate Professor Michael Pollack, Professor Rohan Walker |
Scheme | Research Project |
Role | Lead |
Funding Start | 2023 |
Funding Finish | 2024 |
GNo | G2301113 |
Type Of Funding | C3100 – Aust For Profit |
Category | 3100 |
UON | Y |
QBE and CRI Psychological Illness Strategic Partnership$185,000
Funding body: QBE Insurance (Australia) Ltd
Funding body | QBE Insurance (Australia) Ltd |
---|---|
Project Team | Professor Michael Nilsson, Professor Sarah Johnson, Conjoint Associate Professor Michael Pollack, Professor Rohan Walker |
Scheme | Strategic Partnership Grant |
Role | Lead |
Funding Start | 2023 |
Funding Finish | 2023 |
GNo | G2300006 |
Type Of Funding | C3100 – Aust For Profit |
Category | 3100 |
UON | Y |
Global gene expression changes in the brain following clopidogrel treatment post-stroke$14,767
Funding body: Hunter New England Local Health District
Funding body | Hunter New England Local Health District |
---|---|
Project Team | Doctor Marina Paul, Doctor Madeleine Hinwood, Professor Michael Nilsson, Conjoint Associate Professor Michael Pollack, Professor Rohan Walker |
Scheme | John Hunter Hospital Charitable Trust Grant |
Role | Investigator |
Funding Start | 2023 |
Funding Finish | 2023 |
GNo | G2300310 |
Type Of Funding | C2400 – Aust StateTerritoryLocal – Other |
Category | 2400 |
UON | Y |
20222 grants / $960,484
How can promotion of physical activity after stroke or transient ischemic attach work remotely? Evaluation of a digital tool to improve cardiovascular health and wellbeing$950,000
Funding body: Swedish Research Council for Health, Working Life and Welfare
Funding body | Swedish Research Council for Health, Working Life and Welfare |
---|---|
Project Team | Professor Coralie English, Dr Sara Garcia-Ptacek, Professor Charlotte Hager, Docent Sverker Johansson, Professor Michael Nilsson, Professor Carl Johan Sundberg, Professor Lena Von Koch |
Scheme | FORTE |
Role | Lead |
Funding Start | 2022 |
Funding Finish | 2025 |
GNo | |
Type Of Funding | International - Competitive |
Category | 3IFA |
UON | N |
Antiplatelet medications and cognitive function post-stroke$10,484
Funding body: Hunter New England Local Health District
Funding body | Hunter New England Local Health District |
---|---|
Project Team | Doctor Marina Paul, Doctor Madeleine Hinwood, Professor Michael Nilsson, Conjoint Associate Professor Michael Pollack, Professor Rohan Walker |
Scheme | John Hunter Hospital Charitable Trust Grant |
Role | Investigator |
Funding Start | 2022 |
Funding Finish | 2022 |
GNo | G2200205 |
Type Of Funding | C2400 – Aust StateTerritoryLocal – Other |
Category | 2400 |
UON | Y |
20215 grants / $1,472,320
Yarning up After Stroke$502,208
Funding body: Department of Health and Aged Care
Funding body | Department of Health and Aged Care |
---|---|
Project Team | Conjoint Professor Chris Levi, Professor Kim Usher, Doctor Heidi Janssen, Reakeeta Smallwood, Reakeeta Smallwood, Rachel Peake, Professor Neil Spratt, Professor Michael Nilsson, Professor Liz Holliday, Doctor Carlos Garcia Esperon, Professor Natalie Ciccone, Natalie Ciccone |
Scheme | MRFF - Cardiovascular Health Mission - Cardiovascular Health |
Role | Investigator |
Funding Start | 2021 |
Funding Finish | 2024 |
GNo | G2100012 |
Type Of Funding | C1300 - Aust Competitive - Medical Research Future Fund |
Category | 1300 |
UON | Y |
Using a national level multi-registry analysis to determine whether prescribed anti-platelet therapies post-stroke can modify the risk of cognitive decline or dementia$457,930
Funding body: NHMRC (National Health & Medical Research Council)
Funding body | NHMRC (National Health & Medical Research Council) |
---|---|
Project Team | Professor Michael Nilsson, Professor Rohan Walker, Frederick Walker, Georg Kuhn, Georg Kuhn, Professor John Attia, Sara Gustavsson, Dr Sara Gustavsson, Georg Kuhn, Doctor Madeleine Hinwood, Jenny Nyberg, Dr Jenny Nyberg, Jenny Nyberg, Doctor Christopher Oldmeadow, Doctor Marina Paul, Sara Gustavsson, Professor Neil Spratt, Professor Chris Levi, Dr Leeanne Carey |
Scheme | Ideas Grants |
Role | Lead |
Funding Start | 2021 |
Funding Finish | 2023 |
GNo | G2000554 |
Type Of Funding | C1100 - Aust Competitive - NHMRC |
Category | 1100 |
UON | Y |
EngAGE: A Strategy for Improving Mental, Physical, and Social Wellbeing through Interactive Exercise on the Central Coast$250,000
Funding body: Hunter New England and Central Coast Primary Health Network (HNECC)
Funding body | Hunter New England and Central Coast Primary Health Network (HNECC) |
---|---|
Project Team | Professor Rohan Walker, Doctor Nattai Borges, Dr NICOLETTE Hodyl, Professor Michael Nilsson, Associate Professor Michael Pollack |
Scheme | Research Grant |
Role | Investigator |
Funding Start | 2021 |
Funding Finish | 2022 |
GNo | G2100740 |
Type Of Funding | C3200 – Aust Not-for Profit |
Category | 3200 |
UON | Y |
CRI Strategic Advisory Program$244,000
Funding body: QBE Insurance (Australia) Ltd
Funding body | QBE Insurance (Australia) Ltd |
---|---|
Project Team | Professor Michael Nilsson, Conjoint Associate Professor Michael Pollack, Professor Rohan Walker |
Scheme | Local Grants |
Role | Lead |
Funding Start | 2021 |
Funding Finish | 2022 |
GNo | G2101111 |
Type Of Funding | C3100 – Aust For Profit |
Category | 3100 |
UON | Y |
Determine whether prescribed anti-platelet therapies such as Clopidogrel can modify the risk of cognitive decline or dementia post-stroke$18,182
Funding body: Hunter New England Local Health District
Funding body | Hunter New England Local Health District |
---|---|
Project Team | Conjoint Associate Professor Michael Pollack, Doctor Marina Paul, Doctor Madeleine Hinwood, Professor Michael Nilsson, Professor Rohan Walker |
Scheme | John Hunter Hospital Charitable Trust Grant |
Role | Investigator |
Funding Start | 2021 |
Funding Finish | 2021 |
GNo | G2100339 |
Type Of Funding | C2400 – Aust StateTerritoryLocal – Other |
Category | 2400 |
UON | Y |
20202 grants / $1,090,418
Reducing debilitating fatigue after stroke to improve Quality of Life$1,038,238
Funding body: Department of Health and Aged Care
Funding body | Department of Health and Aged Care |
---|---|
Project Team | Conjoint Professor Chris Levi, Doctor Andrew Bivard, Professor Mark Parsons, Professor Geoff Donnan, Dr Mark Parsons, Farees Khan, Prof. Farees Khan, Professor Marjory Moodie, Beata Bajorek, A/Prof Beata Bajorek, Professor Ken Butcher, Professor Hugh Markus, Professor Michael Nilsson, Prof Kenneth Butcher |
Scheme | MRFF - RCRDUN - Neurological Disorders |
Role | Investigator |
Funding Start | 2020 |
Funding Finish | 2024 |
GNo | G2000065 |
Type Of Funding | C1300 - Aust Competitive - Medical Research Future Fund |
Category | 1300 |
UON | Y |
Understanding awareness, barriers and enablers that affect rehabilitation decisions to support equitable access to rehabilitative care$52,180
Funding body: Medibank Private Ltd
Funding body | Medibank Private Ltd |
---|---|
Project Team | Professor Michael Nilsson, Professor Rohan Walker, Dr NICOLETTE Hodyl, Professor Sarah Johnson, Ms GILLIAN Mason, Associate Professor Michael Pollack |
Scheme | Research Grant |
Role | Lead |
Funding Start | 2020 |
Funding Finish | 2020 |
GNo | G2000306 |
Type Of Funding | C3100 – Aust For Profit |
Category | 3100 |
UON | Y |
20191 grants / $10,000
HMRI Travel Grant$10,000
Funding body: Hunter Medical Research Institute
Funding body | Hunter Medical Research Institute |
---|---|
Project Team | Professor Michael Nilsson |
Scheme | Project Grant |
Role | Lead |
Funding Start | 2019 |
Funding Finish | 2019 |
GNo | G1901274 |
Type Of Funding | C3200 – Aust Not-for Profit |
Category | 3200 |
UON | Y |
20187 grants / $2,716,458
Development and implementation of an advanced clinical decision-making support tool for the delivery of efficient, personalised rehabilitation for patients undergoing total knee arthroplasty (TKA)$1,473,200
Funding body: Ramsay Hospital Research Foundation Ltd
Funding body | Ramsay Hospital Research Foundation Ltd |
---|---|
Project Team | Professor Michael Nilsson, Professor Rohan Walker, Professor Sarah Johnson, Associate Professor Adrian Wills, Doctor Nattai Borges, Associate Professor Michael Pollack |
Scheme | Research Project |
Role | Lead |
Funding Start | 2018 |
Funding Finish | 2021 |
GNo | G1801043 |
Type Of Funding | C3200 – Aust Not-for Profit |
Category | 3200 |
UON | Y |
Microglial paralysis in post-stroke neurodegeneration: help or hinderance?$527,180
Funding body: NHMRC (National Health & Medical Research Council)
Funding body | NHMRC (National Health & Medical Research Council) |
---|---|
Project Team | Professor Rohan Walker, Professor Neil Spratt, Professor Michael Nilsson |
Scheme | Project Grant |
Role | Investigator |
Funding Start | 2018 |
Funding Finish | 2020 |
GNo | G1700229 |
Type Of Funding | C1100 - Aust Competitive - NHMRC |
Category | 1100 |
UON | Y |
Stroke induced disturbances in glymphatic clearance: implications for brain repair?$505,919
Funding body: NHMRC (National Health & Medical Research Council)
Funding body | NHMRC (National Health & Medical Research Council) |
---|---|
Project Team | Professor Rohan Walker, Professor Neil Spratt, Professor Michael Nilsson |
Scheme | Project Grant |
Role | Investigator |
Funding Start | 2018 |
Funding Finish | 2020 |
GNo | G1700230 |
Type Of Funding | C1100 - Aust Competitive - NHMRC |
Category | 1100 |
UON | Y |
Stroke Finder Helmet - saving time, saving brain!$96,000
Funding body: Hunter Medical Research Institute
Funding body | Hunter Medical Research Institute |
---|---|
Project Team | Conjoint Professor Chris Levi, Professor Michael Nilsson |
Scheme | Project Grant |
Role | Investigator |
Funding Start | 2018 |
Funding Finish | 2019 |
GNo | G1800503 |
Type Of Funding | C3200 – Aust Not-for Profit |
Category | 3200 |
UON | Y |
A network of sites and ‘up-skilled’ therapists to deliver best practice stroke rehabilitation of the upper limb$82,159
Funding body: NHMRC (National Health & Medical Research Council)
Funding body | NHMRC (National Health & Medical Research Council) |
---|---|
Project Team | Dr Leeanne Carey, Professor Michael Nilsson, Professor Vincent Thijs, Dr Dominique Cadilhac, Associate Professor Natasha Lannin, Professor Susan Hillier, Professor Geoffrey Donnan, Professor Meg Morris, Professor Leonid Churilov, Professor Marion Walker |
Scheme | Partnership Projects |
Role | Lead |
Funding Start | 2018 |
Funding Finish | 2021 |
GNo | G1800703 |
Type Of Funding | C1100 - Aust Competitive - NHMRC |
Category | 1100 |
UON | Y |
Growth hormone As Neurorestorative Therapy After Stroke$22,000
Funding body: Hunter Medical Research Institute
Funding body | Hunter Medical Research Institute |
---|---|
Project Team | Doctor Lin Kooi Ong, Professor Michael Nilsson, Professor Rohan Walker, Professor Jorgen Isgaard |
Scheme | Project Grant |
Role | Investigator |
Funding Start | 2018 |
Funding Finish | 2018 |
GNo | G1800846 |
Type Of Funding | C3300 – Aust Philanthropy |
Category | 3300 |
UON | Y |
The glymphatic system: A brain waste clearance pathway as a potential target for post-stroke cognitive impairment$10,000
Funding body: Hunter Medical Research Institute
Funding body | Hunter Medical Research Institute |
---|---|
Project Team | Miss Sonia Sanchez Bezanilla, Doctor Lin Kooi Ong, Professor Rohan Walker, Professor Michael Nilsson |
Scheme | Greaves Family Postgraduate Top Up Scholarship in Medical Research |
Role | Investigator |
Funding Start | 2018 |
Funding Finish | 2018 |
GNo | G1801355 |
Type Of Funding | C3300 – Aust Philanthropy |
Category | 3300 |
UON | Y |
20175 grants / $841,772
A scalable intervention for increasing vigorous physical activity among older adolescents: The 'Burn to Learn' cluster RCT$661,293
Funding body: NHMRC (National Health & Medical Research Council)
Funding body | NHMRC (National Health & Medical Research Council) |
---|---|
Project Team | Professor David Lubans, Professor Philip Morgan, Professor Ronald Plotnikoff, Professor Michael Nilsson, A/Prof Chris Lonsdale, Associate Professor Narelle Eather, Doctor Jordan Smith, Professor Charles Hillman |
Scheme | Project Grant |
Role | Investigator |
Funding Start | 2017 |
Funding Finish | 2020 |
GNo | G1600064 |
Type Of Funding | C1100 - Aust Competitive - NHMRC |
Category | 1100 |
UON | Y |
Burn 2 Learn - improving fitness and well-being in senior school students$127,902
Funding body: NSW Department of Education
Funding body | NSW Department of Education |
---|---|
Project Team | Professor David Lubans, Associate Professor Narelle Eather, Professor Philip Morgan, Doctor Jordan Smith, Professor Ronald Plotnikoff, Professor Michael Nilsson, Professor Liz Holliday, A/Prof Chris Lonsdale, Professor Charles Hillman |
Scheme | Research Project |
Role | Investigator |
Funding Start | 2017 |
Funding Finish | 2021 |
GNo | G1700721 |
Type Of Funding | C2300 – Aust StateTerritoryLocal – Own Purpose |
Category | 2300 |
UON | Y |
Using the Swedish National Population Medical Registry System to Explore Predictors of Post-Stroke Mood State and Cognitive Function$27,000
Funding body: Hunter Medical Research Institute
Funding body | Hunter Medical Research Institute |
---|---|
Project Team | Professor Rohan Walker, Professor Michael Nilsson, Professor John Attia, Dr Leeanne Carey |
Scheme | Project Grant |
Role | Investigator |
Funding Start | 2017 |
Funding Finish | 2017 |
GNo | G1700296 |
Type Of Funding | C3300 – Aust Philanthropy |
Category | 3300 |
UON | Y |
Elicitation interviews as a contemplative intervention: insights form stroke into body ownership and agency$21,032
Funding body: Mind and Life Europe
Funding body | Mind and Life Europe |
---|---|
Project Team | Doctor Bryan Paton, Conjoint Professor Chris Levi, Professor Michael Nilsson, Mr Gabriel Axel Montes, Andreas Roepstorff |
Scheme | Research Award |
Role | Investigator |
Funding Start | 2017 |
Funding Finish | 2017 |
GNo | G1700691 |
Type Of Funding | C3500 – International Not-for profit |
Category | 3500 |
UON | Y |
VR Rehab$4,545
Funding body: CSIRO - Commonwealth Scientific and Industrial Research Organisation
Funding body | CSIRO - Commonwealth Scientific and Industrial Research Organisation |
---|---|
Project Team | Doctor Bryan Paton, Conjoint Professor Chris Levi, Professor Michael Nilsson, Mr Gabriel Axel Montes |
Scheme | ON Prime |
Role | Investigator |
Funding Start | 2017 |
Funding Finish | 2017 |
GNo | G1701035 |
Type Of Funding | C2100 - Aust Commonwealth – Own Purpose |
Category | 2100 |
UON | Y |
20162 grants / $20,500
Development and implementation of improved monitoring of psychological stress loads in patients recovering from stroke$20,000
Funding body: Hunter Medical Research Institute
Funding body | Hunter Medical Research Institute |
---|---|
Project Team | Conjoint Associate Professor Michael Pollack, Professor Michael Nilsson, Professor Rohan Walker, Doctor Lin Kooi Ong |
Scheme | Research Grant |
Role | Investigator |
Funding Start | 2016 |
Funding Finish | 2017 |
GNo | G1600724 |
Type Of Funding | C3200 – Aust Not-for Profit |
Category | 3200 |
UON | Y |
ComPoSE - Combined Physical and Sensory training to improve arm function after stroke $500
Funding body: University of Newcastle
Funding body | University of Newcastle |
---|---|
Project Team | Professor Paulette Van Vliet, Professor Michael Nilsson, Miss Urvashy Gopaul, Ms Huiqiao Tian |
Scheme | Linkage Pilot Research Grant |
Role | Investigator |
Funding Start | 2016 |
Funding Finish | 2016 |
GNo | G1600920 |
Type Of Funding | Internal |
Category | INTE |
UON | Y |
20156 grants / $2,789,544
Centre for Research Excellence in Stroke Rehabilitation and Brain Recovery$1,223,727
Funding body: NHMRC (National Health & Medical Research Council)
Funding body | NHMRC (National Health & Medical Research Council) |
---|---|
Project Team | Associate Professor Julie Bernhardt, Professor Michael Nilsson, Dr Leeanne Carey, Professor Paulette Van Vliet, Dr Dominique Cadilhac, Professor Christopher Bladin, Professor Sandy Middleton, Professor Geoff Donnan, Professor Mark Parsons, Conjoint Professor Chris Levi, Doctor Nattai Borges, Professor Michael Nilsson, Professor Rohan Walker |
Scheme | Centres of Research Excellence - Centres of Clinical Research Excellence (CRE) |
Role | Lead |
Funding Start | 2015 |
Funding Finish | 2019 |
GNo | G1401448 |
Type Of Funding | C1100 - Aust Competitive - NHMRC |
Category | 1100 |
UON | Y |
Centre for Research Excellence in Stroke Rehabilitation and Brain Recovery$1,223,727
Funding body: NHMRC (National Health & Medical Research Council)
Funding body | NHMRC (National Health & Medical Research Council) |
---|---|
Project Team | Associate Professor Julie Bernhardt, Professor Michael Nilsson, Dr Leeanne Carey, Professor Paulette Van Vliet, Dr Dominique Cadilhac, Professor Christopher Bladin, Professor Sandy Middleton, Professor Geoff Donnan, Professor Mark Parsons, Conjoint Professor Chris Levi, Doctor Nattai Borges, Professor Michael Nilsson, Professor Rohan Walker |
Scheme | Centres of Research Excellence - Centres of Clinical Research Excellence (CRE) |
Role | Lead |
Funding Start | 2015 |
Funding Finish | 2019 |
GNo | G1401448 |
Type Of Funding | C1100 - Aust Competitive - NHMRC |
Category | 1100 |
UON | Y |
Portable motor rehab device to improve arm movement after stroke$241,064
Funding body: NHMRC (National Health & Medical Research Council)
Funding body | NHMRC (National Health & Medical Research Council) |
---|---|
Project Team | Professor Paulette Van Vliet, Associate Professor James Welsh, Professor Michael Nilsson, MELISSA Knight, Professor Irene Hudson, Mr Jeffrey Julian, Mr Luke Simmons |
Scheme | Development Grants |
Role | Investigator |
Funding Start | 2015 |
Funding Finish | 2016 |
GNo | G1400746 |
Type Of Funding | Aust Competitive - Commonwealth |
Category | 1CS |
UON | Y |
Light Sheet Microscope Facility$55,026
Funding body: Hunter Medical Research Institute
Funding body | Hunter Medical Research Institute |
---|---|
Project Team | Professor Michael Nilsson |
Scheme | Project Grant |
Role | Lead |
Funding Start | 2015 |
Funding Finish | 2017 |
GNo | G1501397 |
Type Of Funding | C3300 – Aust Philanthropy |
Category | 3300 |
UON | Y |
Effects of aerobic exercise combined with task-specific training on neuroplasticity in (sub) chronic stroke$36,000
Funding body: National Stroke Foundation
Funding body | National Stroke Foundation |
---|---|
Project Team | Professor Paulette Van Vliet, Professor Michael Nilsson |
Scheme | Seed Grant |
Role | Investigator |
Funding Start | 2015 |
Funding Finish | 2016 |
GNo | G1500579 |
Type Of Funding | Grant - Aust Non Government |
Category | 3AFG |
UON | Y |
Jennie Thomas Medical Research Travel Grant$10,000
Funding body: Hunter Medical Research Institute
Funding body | Hunter Medical Research Institute |
---|---|
Project Team | Professor Paulette Van Vliet, Professor Michael Nilsson, Emeritus Professor Robin Callister, Miss Sarah Valkenborghs |
Scheme | Jennie Thomas Medical Research Travel Grant |
Role | Investigator |
Funding Start | 2015 |
Funding Finish | 2015 |
GNo | G1500652 |
Type Of Funding | Grant - Aust Non Government |
Category | 3AFG |
UON | Y |
20145 grants / $579,967
Altering the Rehabilitation Environment to Improve Stroke Survivor Activity (AREISSA): A Phase II Trial.$264,241
Funding body: National Heart Foundation of Australia
Funding body | National Heart Foundation of Australia |
---|---|
Project Team | Professor Neil Spratt, Associate Professor Louise Ada, Professor Michael Nilsson, Professor Sandy Middleton, Associate Professor Julie Bernhardt, Professor Leonid Churilov, Conjoint Professor Chris Levi, Conjoint Associate Professor Michael Pollack, Associate Professor Steven Faux, Professor Lin Perry, Dr Annie McCluskey |
Scheme | NSW Cardiovascular Research Network (CVRN) Research Development Project Grant |
Role | Investigator |
Funding Start | 2014 |
Funding Finish | 2015 |
GNo | G1301044 |
Type Of Funding | C3200 – Aust Not-for Profit |
Category | 3200 |
UON | Y |
Investigating the neuroprotective effects of growth hormone$180,726
Funding body: University of Gothenburg
Funding body | University of Gothenburg |
---|---|
Project Team | Professor Rohan Walker, Professor Michael Nilsson, Professor Jorgen Isgaard |
Scheme | Research Grant |
Role | Investigator |
Funding Start | 2014 |
Funding Finish | 2017 |
GNo | G1301437 |
Type Of Funding | C3500 – International Not-for profit |
Category | 3500 |
UON | Y |
The Nanostring nCounter System$75,000
Funding body: Ramaciotti Foundations
Funding body | Ramaciotti Foundations |
---|---|
Project Team | Professor Darryl Knight, Professor Phil Hansbro, Professor Paul Foster, Professor Rodney Scott, Conjoint Professor Peter Gibson, Professor Michael Nilsson |
Scheme | Major Equipment Award |
Role | Investigator |
Funding Start | 2014 |
Funding Finish | 2014 |
GNo | G1300853 |
Type Of Funding | Grant - Aust Non Government |
Category | 3AFG |
UON | Y |
The Nanostring nCounter System$40,000
Funding body: Hunter Medical Research Institute
Funding body | Hunter Medical Research Institute |
---|---|
Project Team | Professor Darryl Knight, Professor Phil Hansbro, Professor Paul Foster, Professor Rodney Scott, Conjoint Professor Peter Gibson, Professor Michael Nilsson |
Scheme | Equipment Grant |
Role | Investigator |
Funding Start | 2014 |
Funding Finish | 2014 |
GNo | G1301083 |
Type Of Funding | Other Public Sector - State |
Category | 2OPS |
UON | Y |
The Nanostring nCounter System$20,000
Funding body: John Hunter Hospital Charitable Trust
Funding body | John Hunter Hospital Charitable Trust |
---|---|
Project Team | Professor Darryl Knight, Professor Phil Hansbro, Professor Paul Foster, Professor Rodney Scott, Conjoint Professor Peter Gibson, Professor Michael Nilsson |
Scheme | Research Grant |
Role | Investigator |
Funding Start | 2014 |
Funding Finish | 2014 |
GNo | G1301084 |
Type Of Funding | Other Public Sector - State |
Category | 2OPS |
UON | Y |
20131 grants / $110,000
Enriched Environment in Rehabilitation - A Phase II Trial$110,000
Funding body: Hunter Medical Research Institute
Funding body | Hunter Medical Research Institute |
---|---|
Project Team | Doctor Heidi Janssen, Professor Neil Spratt, Professor Michael Nilsson |
Scheme | Project Grant |
Role | Investigator |
Funding Start | 2013 |
Funding Finish | 2014 |
GNo | G1300569 |
Type Of Funding | C3300 – Aust Philanthropy |
Category | 3300 |
UON | Y |
Research Supervision
Number of supervisions
Past Supervision
Year | Level of Study | Research Title | Program | Supervisor Type |
---|---|---|---|---|
2023 | PhD | Measuring Research Impact in Australia's Medical Research Institutes: Prioritising Productivity within Research Impact Assessment (to optimise the value from investment into health and medical research) | PhD (Health Economics), College of Health, Medicine and Wellbeing, The University of Newcastle | Co-Supervisor |
2023 | PhD | Development and Evaluation of an Individualised, App-Delivered Psychological Flexibility Skills training Intervention for Medical Student Burnout and Wellbeing | PhD (Public Health & BehavSci), College of Health, Medicine and Wellbeing, The University of Newcastle | Principal Supervisor |
2022 | PhD | From Business as Usual to Making Changes: Perceptions of Physical Activity and Secondary Stroke Prevention after Transient Ischemic Attack or Mild Stroke | PhD (Physiotherapy), College of Health, Medicine and Wellbeing, The University of Newcastle | Co-Supervisor |
2020 | PhD | Functional Deficits after Stroke: The Key Underlying Mechanisms and the Therapeutic Potential of Growth Hormone | PhD (Medical Biochemistry), College of Health, Medicine and Wellbeing, The University of Newcastle | Co-Supervisor |
2020 | PhD | Unraveling the Self: From Bodily Self-Consciousness to Artificial General Intelligence | PhD (Medicine), College of Health, Medicine and Wellbeing, The University of Newcastle | Co-Supervisor |
2020 | PhD | Investigation of Cognition After Stroke - A Translational Approach | PhD (Medical Biochemistry), College of Health, Medicine and Wellbeing, The University of Newcastle | Co-Supervisor |
2019 | PhD | Combined Somatosensory and Motor Training to Improve Upper Limb Recovery After Stroke | PhD (Physiotherapy), College of Health, Medicine and Wellbeing, The University of Newcastle | Co-Supervisor |
2019 | PhD | Enhancing the Efficacy of Task-Specific Training on Upper Limb Motor Recovery after Stroke | PhD (Human Physiology), College of Health, Medicine and Wellbeing, The University of Newcastle | Co-Supervisor |
2019 | PhD | Involvement of Microglia Activation in the Development of CNS Diseases | PhD (Anatomy), College of Health, Medicine and Wellbeing, The University of Newcastle | Co-Supervisor |
2019 | PhD | An Exploration of Low Doses of Exercise on Cardiorespiratory Fitness in People with Chronic Stroke | PhD (Physiotherapy), College of Health, Medicine and Wellbeing, The University of Newcastle | Co-Supervisor |
2018 | PhD | Investigation of Corticosterone Impact on the Sub-Acute Stage of Recovery After Photothrombotic Stroke Induction | PhD (Anatomy), College of Health, Medicine and Wellbeing, The University of Newcastle | Co-Supervisor |
2018 | PhD | Impaired Processes Dynamics of Activated Microglia in Areas of Secondary Neurodegeneration after Ischemic Stroke in Mice | PhD (Anatomy), College of Health, Medicine and Wellbeing, The University of Newcastle | Co-Supervisor |
2017 | PhD | Individual Patient Profiling Using Clinical and Neuroradiological Biomarkers in Acute Ischemic Stroke: Application of Advanced Multimodal Neuroimaging | PhD (Medicine), College of Health, Medicine and Wellbeing, The University of Newcastle | Co-Supervisor |
2017 | PhD | Environmental Determinants of Neurovascular Remodelling and Strategies to Enhance Recovery After Stroke | PhD (Anatomy), College of Health, Medicine and Wellbeing, The University of Newcastle | Co-Supervisor |
2017 | PhD | Key Mechanisms Underlying Damage and Repair Processes in Sites of Secondary Neurodegeneration after Ischemic Stroke | PhD (Anatomy), College of Health, Medicine and Wellbeing, The University of Newcastle | Co-Supervisor |
News
News • 18 Dec 2020
Great ideas attract $7 million in NHMRC grants
Seven University of Newcastle researchers have been awarded more than $7 million in National Health and Medical Research Council (NHMRC) Ideas Grants, designed to support innovative and creative research projects which address a specific question.
News • 6 Dec 2018
$1.5 million project aiming to deliver ‘precision rehabilitation’
A new decision-making tool being developed in a major research project at the University of Newcastle (UON) and Hunter Medical Research Institute is set to give patients better and more personalised rehabilitation interventions after knee replacement surgery.
News • 12 Oct 2018
Brain fertiliser nurtures new hope for stroke survivors
A hormone already at our fingertips could provide a simple answer for a first-of-its-kind treatment to promote ‘brain fertilisers’ and significantly improve quality of life for stroke survivors, potentially even months or years after experiencing a stroke.
News • 24 Nov 2017
New Centre for Rehab Innovations
Medical rehabilitation services are set for a significant overhaul, following the launch of Australia’s first Centre for Rehab Innovations (CRI) at the University of Newcastle (UON).
News • 16 Jun 2017
Horse riding and rhythm-and-music helping stroke recovery
Horseback riding and rhythm-and-music therapies may improve stroke survivors’ perception of recovery, gait, balance, grip strength and cognition years after their stroke, according to new research in the prestigious American Heart Association’s journal Stroke.
News • 2 Mar 2017
Hunter to test stroke detector
With an acute stroke occurring every 10 minutes in Australia, a revolutionary timesaving diagnostic device called the Stroke Finder helmet is being trialled by the Hunter Medical Research Institute for the first time.
News • 23 Mar 2016
Stroke risk link to mental and physical fitness in teens
Using comprehensive health data from men aged 18, two international studies have highlighted a strong causal link between long-term stroke risk and both cardiovascular and mental fitness in early adulthood.
News • 22 Sep 2015
Hunter research leaders appointed to national research committees
Two medical research leaders from the University of Newcastle have been appointed to high-level advisory committees with the National Health and Medical Research Council (NHMRC).
News • 14 Apr 2015
Funding for stroke rehabilitation
Congratulations to Professor Paulette Van Vliet from the School of Health Sciences on her successful application for an NHMRC Development Grant for the continued development of the Arm Movement Measurement (ArMM) device.
News • 4 Feb 2015
Stroke detector
The Hunter Region NSW will become the international testing ground for a new microwave-imaging headpiece that helps ambulance and emergency teams rapidly diagnose stroke and other traumatic brain injuries.
News • 3 Jun 2014
Major cancer boost
The Hunter Cancer Research Alliance (HCRA) has become the first regionally based organisation to receive full Translational Cancer Research Centre status and an accompanying $6.5-million funding injection from the Cancer Institute NSW.
News • 12 Mar 2014
Exercise key to preventing early-onset dementia
A new international study has shown for the first time that teenagers with poor cardiovascular fitness and a lower IQ have a significantly increased risk of developing early-onset dementia and its precursors.
Professor Michael Nilsson
Position
Honorary Professor
Centre for Rehab Innovations
School of Medicine and Public Health
College of Health, Medicine and Wellbeing
Contact Details
michael.nilsson@newcastle.edu.au | |
Phone | +61 2 4042 0570 |
Mobile | 0417474892 |
Fax | +61 2 4042 0001 |
Links |
Research Networks Research Networks Research Networks |
Office
Building | HMRI Building |
---|---|
Location | Lot 1, Kookaburra Circuit, New Lambton Heights , |